Vitamin Retailer — March 2013
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Supplement Science
Gene Bruno

Stearic Acid & Magnesium Stearate:


Perhaps you’ve read or heard that stearic acid and magnesium stearate are undesirable substances to be included in dietary supplements. Certainly the internet is rife with articles and blogs indicating that these substances are harmful, as well as articles and blogs refuting those claims. So, what is true? Let’s examine the facts.

We’ll begin by defining stearic acid and magnesium stearate. Stearic acid is a saturated fatty acid found in many foods including animal and vegetable fats and oils.1 Cocoa2 and flaxseed3 are examples of foods that contain substantial amounts of stearic acid. Magnesium stearate is a magnesium salt of stearic acid. In other words, it is a compound containing two stearic acids and one magnesium.

The Fate of Stearic Acid & Magnesium Stearate in the Body

In the body, stearic acid is primarily converted into oleic acid (a monounsaturated fatty acid).4 Oleic acid comprises the majority of olive oil, and may also be found in substantial quantities in grape seed oil, sea buckthorn oil and the açaí berry.5,6 In addition, oleic acid may be responsible for the blood pressure reducing effects of olive oil.7 Consequently, even though stearic acid is a saturated fat, studies have suggested that it has no negative effect on blood cholesterol levels since such a high proportion is converted to oleic acid.8 In fact, some research even indicates that stearic acid actually lowers LDL cholesterol.9

After magnesium stearate is broken back down into its component parts in the body, its fat is essentially the same as that of stearic acid. The magnesium part of it can be used to supply the body with this essential mineral.

Using Them in Dietary Supplements

Stearic acid is commonly used as a binder in tablets (think of how you might use eggs as a binder to mix with flour during baking). It also has lubricant properties. Magnesium stearate is a lubricant, and the most common ingredient used in tablet formulations. After achieving a homogenous blend of powdered ingredients, a small amount of magnesium stearate is added to enable the powder blend particle surface to be sufficiently coated while limiting penetration of the lubricant within the particle matrix.10 This will allow tablets to be punched without sticking to the machinery, or capsules to glide shut easily and eject from the machinery.

It should be noted that the amounts of stearic acid and magnesium stearate typically used in a tablet is relatively minute. Stearic acid typically ranges between 0.5-10 percent of the tablet weight, while magnesium stearate typically represents 0.25-1.5 percent of the tablet weight.11 Therefore, in a 500 mg tablet, the amount of stearic acid would probably be about 25 mg, and magnesium stearate about 5 mg.

Alleged Problems

There are a few alleged problems with the use of stearic acid and magnesium stearate in dietary supplements. The first is that magnesium stearate will interfere with absorption of the nutrients in the tablet. Supposedly, magnesium stearate promotes the growth of gastrointestinal bacterial colonies, which in turn create a biofilm that prevents the absorption of nutrients. While it is true that some bacteria form biofilms on surfaces to protect themselves from antimicrobial attack, it is also true that biofilms help the bacteria to communicate, colonize, defend against competitors, adapt to changing environments and are vital to our human microbiota (i.e., not all biofilms are bad).12 In any case, the problem with the allegation that there is no research suggesting or proving biofilms occur in humans with ingestion of magnesium stearate, although there is a laboratory study that found stearic acid to inhibit the formation of biofilms.13

In any case, this concept loses credibility when you consider how easy it would be to consume far more stearic acid in a regular meal than you would in a dietary supplement tablet. For example, if you ate a piece of roasted chicken [chicken thigh, meat only (skin removed), roasted], you’d get about 359 mg of stearic acid.14 Likewise, if you ate half of a bar of milk chocolate (about 112 calories), you’d get 1,283 mg of stearic acid. Also, according to, USDA (U.S. Department of Agriculture) nutrition surveys indicate that the average American adult consumes between 5,900-8,800 mg stearic acid each day (typically from food sources like beef, poultry, cocoa butter, milk and cheese). So, if you were to follow this concept to its logical conclusion, you’d have to avoid all food that contains stearic acid when you take your supplements. Clearly this makes no sense. People routinely take their supplements with meals, yet they still absorb the nutrients provided by those supplements.15 So compared to hundreds of milligrams of stearic acid in a meal, what’s the big deal about 5-25 mg of magnesium stearate or stearic acid in a supplement? Answer: there is none.

Another alleged problem with stearic acid and magnesium stearate in dietary supplements is concerns about their potential negative effect on immunity. The primary source for this concern is a scientific journal article, “Molecular basis for the immunosuppressive action of stearic acid on T cells.”16 This article reports an in-vitro experiment where stearic acid suppressed the immune activity of T cells. In reading this article, it is important to consider a few things. First, T-cells lack the enzymatic machinery to metabolize stearic acid, which makes the findings of that study a bit suspicious.17 Secondly, the total concentration of free fatty acids in the plasma of a healthy adult is about 100 times less18 than the amount of free stearic acid it took to kill the T-cells in vitro. In other words, this couldn’t happen in real life.

So what does happen when stearic acid is provided to humans in normal amounts? In one study, immune competence was tested by a battery of T- and B-lymphocyte stimulation tests and also by natural killer (NK) cell activity in a group of 94 men receiving different fatty acids, including stearic acid. The results were that stearic acid was found to have a positive effect on immunity, particularly NK cell activity.19 In any case, whether the effects on immunity were positive or negative, the amount of stearic acid and magnesium stearate found in dietary supplements is still too insignificant to matter.

It is interesting to note that research in rats found that even when magnesium stearate was fed to them in quantities representing five percent of their diet, there were no negative effects. Harm to the rats occurred only when the magnesium stearate was increased to 10-20 percent of their diet. (Just to be clear, five percent of their diet corresponds to 2,500 mg/kg of body weight per day.20) Of course, too much of anything is not good for you, but in order to consume such large amounts of magnesium stearate from supplements, humans would have to take thousands of capsules/tablets daily. This is something that even the most ardent supplement user could not achieve—although if they could, the animal research suggests that even at five percent of the diet, there would still be no harm (at least from the magnesium stearate).


There does not appear to be any advantage to avoiding stearic acid and magnesium stearate in dietary supplements. The objections raised are not borne by research. Both of these substances are safe and essentially harmless in the amounts used in dietary supplements. Furthermore, if magnesium stearate is eliminated from the tablet/capsule manufacturing process, the machines used to produce them will have to do smaller runs and be cleaned more frequently to avoid gumming up the works. The result will be an increase in labor and costs. Naturally, those costs will be reflected in the price of the finished product. That’s an unnecessary price increase considering there is no value in avoiding magnesium stearate or stearic acid in the first place.


1 Whitney EN, Rolfes SR. Understanding Nutrition, 9th ed. Belmont, CA: Wadsworth/Thomson Learning; 2002.

2 Steinberg FM, Bearden MM, Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc. 2003;103(2):215-23.

3 Babu US, Bunning VK, Wiesenfeld P, Raybourne RB, O'Donnell M. Effect of dietary flaxseed on fatty acid composition, superoxide, nitric oxide generation and antilisterial activity of peritoneal macrophages from female Sprague-Dawley rats. Life Sci. 1997;60(8):545-54.

4 Emken EA. Metabolism of dietary stearic acid relative to other fatty acids in human subjects. Am J Clin Nutr. 1994; 60(6):1023S–1028S.

5 Thomas R. Fats and Fatty Oils. In Ullmann's Encyclopedia of Industrial Chemistry, Wienheim: Wiley- VCH; 2002.

6 Schauss AG, Wu X, Prior RL, Ou B, Patel D, Huang D, Kababick JP. Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae Mart. (acai). J Agric Food Chem. 2006;54(22):8598-603.

7 Terés, S; Barceló-Coblijn, G; Benet, M; Alvarez, R; Bressani, R; Halver, Je; Escribá, Pv (Sept. 2008). Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proc Natl Acad Sci USA. 2008;105:13811.

8 Stearic acid. American Heart Association; 2009

9 Mensink RP. Effects of stearic acid on plasma lipid and lipoproteins in humans. Lipids. 2005;40(12):1201-5.

10 Brown B. Magnesium Stearate and Tableting Lubrication. Natural Product Insider 2008; April.

11 Rowley FA. Formulating Nutritional Supplement Tablets and Capsules. Vallejo, CA: Solid Dosage Training, Inc; 2007.

12 Elias S, Banin E. Multi-species biofilms: living with friendly neighbors. FEMS Microbiol Rev. 2012 Jan 9. Doi: 10.1111/j.1574-6976.2012.00325.x. [Epub ahead of print].

13 Soni KA, Jesudhasan P, Cepeda M, et al. Identification of ground beef-derived fatty acid inhibitors of autoinducer-2-based cell signaling. J Food Prot. 2008 Jan;71(1):134-8.

14 USDA National Nutrient Database for Standard Reference, Release 21;2008.

15 Hansen C, Werner E, Erbes HJ, Larrat V, Kaltwasser JP. Intestinal calcium absorption from different calcium preparations: influence of anion and solubility. Osteoporos Int. 1996;6:386-93.

16 Tebbey PW, Buttke TM. Molecular basis for the immunosuppressive action of stearic acid on T cells. Immunology. 1990 70 379-384.

17 Buttke TM, Van Cleave S, Steelman L, McCubrey JA. Absence of unsaturated fatty acid synthesis in murine T lymphocytes. Proc Natl Acad Sci USA. 1989; 86(16):6133–6137.

18 Leaf A. Plasma Nonesterified Fatty Acid Concentration as a Risk Factor for Sudden Cardiac Death: The Paris Prospective Study. Circulation. 2001;104:744.

19 Berry EM, Hirsch J, Most J, McNamara DJ, Cunningham-Rundles S. Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. Nutr Cancer. 1987;9(2-3):129-42.

20 Søndergaard D, Meyer O, Würtzen G. Magnesium stearate given perorally to rats. A short term study. Toxicology. 1980;17(1):51-5.

Gene Bruno, MS, MHS, the dean of academics for Huntington College of Health Sciences, is a nutritionist, herbalist, writer and educator. For more than 30 years he has educated and trained natural product retailers and health care professionals, has researched and formulated natural products for dozens of dietary supplement companies, and has written articles on nutrition, herbal medicine, nutraceuticals and integrative health issues for trade, consumer magazines and peer-reviewed publications.