Vitamin Retailer November 2012 : Page 34

2012 2012 Science Science of of Supplements: Supplements: Winter Winter Issue Issue ver need a one-page reference arti-cle to help you decide if you want to carry a product in your store, or to refer a customer to when they’re ask-ing about the research behind a particu-lar product? Look no further. This special section of Vitamin Retailer comes in response to the industry’s desire for more information—retailers wanting more information about the products they sell and manufacturers wanting to offer the science that backs the effectiveness of their products. We have featured a similar section annually in Vitamin Retailer’ s sister publication, Nutrition Industry Executive , since 2002, where it is designed to help manufactur-ers gain a better understanding of the ingredients and services available that can make their products stand out. Vitamin Retailer is once again respond-ing to retailers’ increased demand for science and research by offering this sec-tion twice—first in our May issue with our Summer installment, and here again in our November issue—providing com-panies with two opportunities to describe in some detail to you, our read-ers, the insight and research that goes into their products. Manufacturers have responded to this opportunity with background informa-tion about the health concerns their products are intended to address, histo-ries of the nutrients behind their prod-ucts and details of research carried out on their products. We’ve also provided company addresses, phone numbers and website addresses to make obtain-ing additional information easier. E Following is an index of companies participating in the 2012 VR Science of Supplements: Winter Issue section: ANTIAGING Institute of California ..........35 Bluebonnet Nutrition Corporation ..........36 Fairhaven Health ......................................37 InBalance Health Corporation..................38 Life Extension ..........................................39 NaturaNectar LLC ....................................40 Nordic Naturals ........................................41 NOW Foods ............................................42 Nutrex Hawaii ..........................................43 Onnit Labs, LLC ......................................44 Pharmachem Laboratories Inc. ................45 Superior Source........................................46 Wakunaga of America Co., Ltd. ..............47 ZyCal Bioceuticals, Inc. ............................48 34 VITAMIN RETAILER WWW.VITAMINRETAILER.COM s NOVEMBER 2012

Science Of Supplements: Winter Issue

Ever need a one-page reference article to help you decide if you want to carry a product in your store, or to refer a customer to when they’re asking about the research behind a particular product? Look no further.<br /> <br /> This special section of Vitamin Retailer comes in response to the industry’s desire for more information—retailers wanting more information about the products they sell and manufacturers wanting to offer the science that backs the effectiveness of their products. We have featured a similar section annually in Vitamin Retailer’s sister publication, Nutrition Industry Executive, since 2002, where it is designed to help manufacturers gain a better understanding of the ingredients and services available that can make their products stand out.<br /> <br /> Vitamin Retailer is once again responding to retailers’ increased demand for science and research by offering this section twice—first in our May issue with our Summer installment, and here again in our November issue—providing companies with two opportunities to describe in some detail to you, our readers, the insight and research that goes into their products.<br /> <br /> Manufacturers have responded to this opportunity with background information about the health concerns their products are intended to address, histories of the nutrients behind their products and details of research carried out on their products. We’ve also provided company addresses, phone numbers and website addresses to make obtaining additional information easier.<br /> <br /> ANTIAGING Institute of California<br /> <br /> 9301 Wilshire Blvd., Ste. 211<br /> Beverly Hills, CA 90210<br /> Phone: (800) 370-4080<br /> Website:<br /> <br /> Don’t Pause Your Life<br /> <br /> By Shoreh Ershadi, PharmD, PhD, ABAAHP, NRCC, NRCT, ASCP, president and CEO of the ANTIAGING Institute of California<br /> <br /> The link between healthy aging and nutrition is a scientific fact. Nutritional research and accurate information on the active forms and precise concentrations and combinations of ingredients in what we eat can help us choose healthier foods, fruits, nuts and even natural supplements. But natural products, minerals and trace elements are necessary for optimal function of the biochemical pathways at cellular level.<br /> <br /> Don’t Pause is a 100 percent natural healthy “salad” packed into little capsules for fast and easy results. This salad is made out of green tea to help burn fat; pomegranate with antioxidant, antiinflammatory, anti-aging skin benefits; soy isoflavones, selenium and other natural ingredients to help promote cardiovascular health, improve muscle tone and bone density by enhancing calcium absorption. The strong antioxidant effect of Don’t Pause helps to maintain a healthy body through peri-menopause and menopause. Chromium picolinate helps to balance blood sugar and to reduce insulin resistance.<br /> <br /> Selenium’s Protective Role<br /> <br /> Selenium is an essential trace metal required for the function of seleniumdependent enzymes known as selenoproteins or selenoperoxidases. Research has shown that these enzymes are involved in intra- and extra-cellular antioxidant reactions. However, their more subtle function is in controlling the formation of pro-inflammatory cytokines derived from oxidation intermediates that initiate and amplify inflammation. They regulate cancer cell proliferation and are also known to inhibit the factors contributing to the pathogenesis of cardiovascular diseases.<br /> <br /> The major role of selenoperoxidases is the detoxifying process in liver cells neutralizing the damaging effects of chemical drugs, heavy metals and reactive oxygen species or free radicals.<br /> <br /> Oxidation is one of the causes leading to the degenerative symptoms of aging. Prevention now is worth so much more later in life.<br /> <br /> Psoriasis is a chronic immune system skin disease characterized by production of free radicals due to the activation of tumor necrosis factor alpha (TNF-á). Selenium levels in psoriatic patients have been found to be lower than expected, but studies on its role in the pathogenesis of the disease are not defined yet.<br /> <br /> Selenium can influence immune response by changing the expression of cytokines and their receptors or by making immune cells more resistant to oxidative stress. It is reported that selenium supplementation has an inhibitory effects on TNF-á levels in patients with psoriasis. Selenium has been shown to prevent the in vitro release of UVBinduced pro-inflammatory cytokines by inhibition of mRNA in human keratinocytes.<br /> <br /> Antioxidants act synergistically with selenium, which is potentially dependent on optimal selenoperoxidase activity. The protective role of selenium in oxidative stress, lipid peroxidation and immune system regulations, emphasizes the importance of achieving adequate selenium intake in the diet.<br /> <br /> Diets with less sugar to prevent inflammation and glycation of the cells and replacing sugary foods with fruits and vegetables (colorful fruits and vegetables are known for their antioxidant benefits), beans and seeds (especially Brazil nuts, which contain a high concentration of selenium) are recommended.<br /> <br /> Powerful Pomegranate<br /> <br /> One of the strongest antioxidants is ellagic acid found in pomegranates. A combination of pomegranate extract and green tea together with other natural ingredients and high absorbing selenium is presented in Don’t Pause for women.<br /> <br /> Take advantage of the latest research and published knowledge to enhance immune responses and protect cells against the oxidative damages of free radicals. Prevent the signs and symptoms of aging and improve quality of life.<br /> <br /> Sources: <br /> <br /> Medline Plus: Green Tea ( druginfo/natural/960.html). <br /> <br /> University of Maryland Medical Center; Selenium; May 2009 ( 000325.htm). <br /> <br /> Medline Plus: Psoriasis ( ency/article/000434.htm).<br /> <br /> References:<br /> <br /> Pomegranate juice is rich in tannins, possesses anti-atherosclerotic properties, has anti-aging effects, and potent antioxidative characteristics. As some antioxidants. All rights reserved. PMID: 21457902; [PubMed - indexed for MEDLINE].<br /> <br /> Therapeutic Applications of Pomegranate (Punica granatum L.): A Review. Alternative Medicine Review, Volume 13, Number 2 2008.<br /> <br /> Naziroglu M. Yidiz K, Tamtürk B, Erturan I, Flores- Arce M. Selenium and Psoriasis. Biol Trace Elem Res. 2012 Jul 24. [Epub ahead of print].<br /> <br /> Kharaeva Z, Gostova E, De Luca C, Raskovic D, Korkina L. Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation topsoriasis patients. Nutrition, 2009 Mar;25(3):295- 302. Epub 2008 Nov 28.<br /> <br /> Serwin AB, et al. Selenium Nutritional Status and the Course of Psoriasis. Pol Merkur Lekarski, 1999 May;6(35):263-5.<br /> <br /> Serwin AB, et al. Selenium Status in Psoriasis and its Relations to the Duration and Severity of the Disease. Nutrition, 2003 Apr;19(4):301-4.<br /> <br /> Fairris GM, et al. The Effect of Supplementation of Vitamin E in Psoriasis. Annals of Clinical Biochemistry, 1989 Jan;26 (Pt 1): 83-88.<br /> <br /> Bluebonnet Nutrition Corporation<br /> <br /> 12915 Dairy Ashford<br /> Sugar Land, TX 77478<br /> Phone: (281) 240-3332<br /> Website:<br /> <br /> Sports Nutrition Facts<br /> <br /> By Trisha Sugarek MacDonald, BS, MS, Director of Research & Development/National Educator<br /> <br /> Q:What are the physiological/ nutritional needs of hardcore bodybuilders/strength and resistance-trained athletes?<br /> <br /> A:Bodybuilders and strength and resistance-trained athletes depend on a diet with an adequate balance of protein, complex carbohydrates, healthy fat, vitamins, minerals and water to ensure optimal performance. A deficiency in any of these essential nutrients significantly impairs performance outcomes.<br /> <br /> A serious athlete’s diet generally contains 2,500-5,500 calories/day for men and 1,500-3,000 calories/day for women, depending on the types and levels of exercise. The ratio of protein, carbohydrate and fat is typically 40 percent, 40 percent and 20 percent, respectively. While there are many variations, ultimately the diet needs to be tailored to the individual based on their physical activity and desired physique. To achieve a bigger, better body, many athletes have placed a huge emphasis on nutrition, supplementation and unfortunately, in many cases, illegal use of steroids or supplement products with unsafe ingredients (e.g., DMAA).<br /> <br /> Q:How have some brands met the challenges associated with the sports nutrition industry?<br /> <br /> A:With increased consumer interest, it has become increasingly clear that not all sports nutrition products are created equal. Since 2007, the FDA has identified more than 300 illegal products marketed as “dietary supplements” or “sports nutrition” that contain hidden drugs, stimulants or other undeclared substances. Because of this, there has been an increase in the regulatory enforcement by the FDA on sports nutrition products in recent years. In addition, the U.S. Anti-Doping Agency (USADA) launched the “Supplement Safety Now” initiative to work with industry leaders to provide consumers with clean, safe products. Bluebonnet Nutrition stepped up to that challenge by launching Extreme Edge®, a line tested and proven to contain no banned substances or harmful ingredients, earning the NSF Certified for Sport® seal.<br /> <br /> Q:What nutrients should consumers look for in preworkout formulas and why?<br /> <br /> A:Simple, fast-acting carbohydrates in conjunction with amino acids (i. E., typically 3-6 g) with a focus on arginine, lysine and the branched chain amino acids (BCAAs), plus responsible amounts of caffeine spur the body into action—not just physically, but mentally. Effective pre-workout formulas like Extreme Edge Pre Workout should help to prepare the body for the rigors of a workout. All of the ingredients listed above will help ignite explosive energy and sharpen mental focus, in addition to CarnoSyn®, the patented and most studied form of beta-alanine, which also helps to increase the concentration of carnosine in the muscles, preparing them for extreme performance while decreasing fatigue.<br /> <br /> Q:What about carbohydrate loading—when/how should athletes go about this?<br /> <br /> A:Carbohydrate formulas can be used to fuel the athlete during training sessions that last longer than an hour, and can help refuel the glycogen stores of the liver and muscles two days prior to a marathon or triathlon event. Currently, the recommendation is 20-60 g of complex carbohydrates/hour in a six to eight percent solution to help push the body through a vigorous workout. An endurance formula like Extreme Edge Carbo Load with complex carbohydrates (i. E., waxy maze, steal cut oats, brown rice and maltodextrin) is important because when refueling the body, one wants carbohydrate sources that don’t just temporarily spike blood glucose levels, but are steady and provide the cells with ample energy so athletes can go the distance. Carbohydrate formulas like Extreme Edge Carbo Load that contain nutrients, such as alpha lipoic acid, cinnamon (Cinnulin PF) and chromium, support glucose and insulin activity so that athletes can avoid the dreaded blood-sugar nosedive.<br /> <br /> Q:What are the current macronutrient recommendations for post-training?<br /> <br /> A:Depending on the sport (i.e., resistance vs. endurance), nutritional recommendations can vary. Many athletes like a 3:1 protein/carbohydrate blend similar to that found in Extreme Edge Post Workout to help support the body during recovery and promote muscle growth. The reason is because the body has a “window of opportunity” to transition from a catabolic to an anabolic state where muscle can be rebuilt and recover properly. This 3:1 ratio allows the athlete to hit the gym the next day with even more intensity than the day before. Effective post-workout formulas should provide at least 150 calories that is comprised of a high-quality, fast-acting protein like whey protein isolate and complex carbohydrates like waxy maize. It should also contain ingredients that support the body in recovery like bromelain from pineapple, glutamine and additional BCAAs in a 4:1:1 ratio to optimize muscle repair. With Extreme Edge Post Workout, each serving should provide naturally occurring minerals, such as calcium, magnesium, sodium, phosphate and potassium, to help replenish electrolytes, which are lost through sweat, to help reduce the risk of cramping and dehydration.<br /> <br /> References: <br /> <br /> Heller, L. (2010, June 3). Sports nutrition market driven by non-sporty consumers. Nutraingredients. Retrieved on December 10, 2010 from www.nutraingredients. com/Consumer-Trends/Sports-nutrition-market- driven-by-non-sporty-consumers.<br /> <br /> Lambert, C. P., Frank, L. L., & Evans, W. J. (2004). Macronutrient considerations for the sport of bodybuilding. Sports Medicine, 34(5), 317-327.<br /> <br /> World Anti-Doping Code (2nd ed.). (2009). Montreal, Quebec: World Anti-Doping Agency.<br /> <br /> Fairhaven Health<br /> <br /> 1200 Harris Ave., Ste. 403<br /> Bellingham, WA 98225<br /> Phone: (360) 543-7888<br /> Fax: (206) 770-6441<br /> E-mail: • Website:<br /> <br /> Male Fertility Supplement Clinically Shown to Improve Sperm Parameters<br /> <br /> Infertility impacts one in six couples with many not realizing that roughly half of all issues can be attributed to the male partner. Most typically poor sperm parameters such as low count, motility or morphology issues (shape of the sperm) are to blame. Unfortunately, not enough men believe there may be a problem or even take the time to get tested.<br /> <br /> Alarmingly, the average sperm count for adult males is said to have decreased by as much as 50 percent since 1938, and is currently declining at a rate of two percent each year, according to a study published in the British Medical Journal. Stress, exposure to environmental toxins and diets deficient in key vitamins and minerals may likely be to blame.<br /> <br /> Data from an independent, doubleblind, placebo-controlled study indicates that the use of the fertility supplement, FertilAid for Men, resulted in marked improvements in male fertility and sperm health. Specifically, the results of this important study reveal that taking FertilAid for Men significantly increases “total normal sperm motility,” with a tendency toward an “increase in total mobile sperm count.”<br /> <br /> Results of the FertilAid for Men study were presented at the American Society of Andrology’s Annual Meeting and revealed a “significant improvement” in sperm parameters suggesting increased odds of pregnancy.<br /> <br /> FertilAid for Men is a comprehensive fertility supplement consisting of vitamins, minerals, antioxidants and the amino acid L-carnitine. Much of the formula is based on scientific literature showing how antioxidants prevent oxidative damage to spermatozoa and enhance the defense mechanisms of seminal plasma which protect and nourish sperm. Central to the FertilAid for Men formula is the blending of key antioxidants, among these vitamins C and E, selenium and a particularly potent source of antioxidants, grapeseed extract. The ingredients are designed to promote healthy sperm count, sperm morphology and sperm motility, while reducing oxidative damage from agents, free radicals, or biological interactions that cause oxidative stress.<br /> <br /> Studies on the amino acid L-carnitine display equally exciting results. L-carnitine has been shown to support sperm metabolism, or the capacity of sperm to transform complex molecules into energy. L-carnitine has been shown in a number of clinical studies to enhance several fundamental sperm parameters, including sperm concentration, motility and normal morphology.<br /> <br /> These same ingredients are commonly recommended by fertility specialists, but are very costly if purchased and consumed separately. Reproductive endocrinologist, Dr. J.E. Ellington, and pharmacologist, Dr. G. D. Clifton, conducted the study over a threemonth period to determine the effects of FertilAid on men with “abnormal sperm parameters,” as defined by the World Health Organization. According to Ellington, “men with higher levels of motile, normally shaped sperm have shown better pregnancy outcomes in several [independent] studies.”<br /> <br /> A defining characteristic of sperm health is sperm motility, or the ability of sperm to move in a progressive, unidirectional manner. Motile sperm display the capacity to swim in a sustained, forward-moving fashion. Importantly, motile sperm also exhibit an increased ability to fertilize an egg. Non-motile or abnormally motile sperm, on the other hand, show a decreased capacity to cause fertilization (or pregnancy).<br /> <br /> In determining healthy sperm function, the “total normal sperm motility” is a fundamental aspect or “parameter” for defining fertility health in human males. The FertilAid for Men study results indicate statistically significant improvements in sperm motility for subjects using the dietary supplement.<br /> <br /> Study designer, Ellington, also suggested that the use of FertilAid for Men may improve sperm counts. The FertilAid study showed a tendency toward an increase in total mobile sperm count, which corroborates previous independent studies focusing on specific ingredients contained in the FertilAid for Men formula—particularly various antioxidants and the amino acid, L-carnitine.<br /> <br /> FertilAid was formulated by Dr. Amos Grunebaum, a leading fertility expert and current director of obstetrics at one of the country’s top university medical centers. Grunebaum noted, “the FertilAid for Men study verifies and bolsters evidence from previous independent studies on nutrition and sperm health. The FertilAid for Men formula is based on previous clinical evidence, and we are pleased to see that this new FertilAid study both confirms and advances research on male fertility and sperm health.”<br /> <br /> For a full list of references and supporting studies on antioxidants, L-carnitine and sperm health for male infertility, visit<br /> <br /> InBalance Health Corporation<br /> <br /> 741 S. Main St.<br /> Wayland MI 49348<br /> Phone: (269) 792-1977<br /> Email:<br /> Website:<br /> <br /> Combating Type 2 Diabetes<br /> <br /> By Don VerHulst, MD, Chief Science Officer at InBalance Health Corporation<br /> <br /> There is no question that type 2 diabetes is one of the fastest growing diseases in history. According to the Centers for Disease Control and Prevention (CDC), there are an estimated 79 million American adults aged 20 years or older with pre-diabetes. Currently the sixth leading cause of death by disease among adults in America, diabetes causes major blood vessel damage, which can lead to heart attack, stroke, nerve damage, kidney disease and even blindness.<br /> <br /> This dreaded disease continues to increase at an alarming rate. The CDC predicts that without major changes in diet and lifestyle, one in three children born in 2000 could end up with diabetes. The question is: Why are we seeing such an increase in this disease? The answer is simple—more than twothirds of adult Americans and one in five children are overweight. The direct correlation between excess weight and blood sugar problems is well known. The problem is not type 2 diabetes; the problem is not dealing with the underlying factors that contribute to it.<br /> <br /> Every journey starts with one small step. The journey to combating obesity and type 2 diabetes is no different. Having a plan to reach one’s ideal weight can make all the difference. So what is this small step? It’s the decision to eat better by: eating real foods not man-made, nutrient-depleted foods; making a commitment to control portion sizes instead of supersizing meals; avoiding skipping meals and even including a power snack between meals; and keeping healthy calories steadily in the body throughout the day.<br /> <br /> Generally, when people want to lose weight they try to cut back on calories by skipping meals. This is a bad idea. Skipping meals puts the body into survival mode. Metabolism, the rate at which we burn calories, decreases as the body prepares for what it perceives as famine. The result is a low-energy state in which one is actually training the body to store fat.<br /> <br /> Successful weight loss means keeping metabolism burning by eating several smaller meals with healthy snacks in between. A healthy snack is one that won't cause the blood sugar to rise too much or too fast. The INBar from InBalance Health was specifically designed to help consumers on their journey to ideal weight management and balanced blood sugar.<br /> <br /> The model healthy snack must contain the proper balance of protein, carbohydrates and fats from a base of real, unprocessed foods. It should provide enough calories and fiber to satisfy an appetite. Oh, and wouldn't it be great if it could sustain your energy level and keep metabolism burning between meals by using a blend of slow-release, natural carbohydrates that won’t cause the blood sugar fluctuations typically associated with snacking? Finally, it should also taste good and not contain any of the most common allergens such as gluten, wheat, dairy, soy, nuts, corn and eggs.<br /> <br /> The INBar was formulated to provide a healthy, natural snack or mini-meal for the 79 million Americans with pre-diabetes or type 2 diabetes, and the twothirds of American adults who are overweight.<br /> <br /> The specially selected, slowly digested carbohydrates found in the INBar can help minimize blood sugar spikes and manage hunger, while INBar’s organic sunflower seed butter, organic rice bran fiber and organic crispy brown rice provide a slow release of nutrients to avoid excessive blood sugar fluctuation. Additionally, mulberry leaf extract is included for its amazing ability to stabilize blood sugar.<br /> <br /> The mulberry leaf contains specific iminosugars, also called azasugars, which are potent blockers of carbohydrate breakdown after a meal. The most abundant and bioactive carbohydrate blocker is an iminosugar known as 1-deoxynojirimycin (DNJ). DNJ is a very potent glucosidase inhibitor, which is the enzyme system responsible for breaking down carbohydrates into simple sugars. When the glucosidase enzyme does its job, complex carbohydrates are digested and glucose is released.<br /> <br /> Glucose is the simple sugar that determines one’s blood sugar level. By slowing down the intestinal digestion of carbohydrates, DNJ can potentially help the body control excessive blood sugar increases. This is very exciting, since the rapid rise in blood sugar level after eating can be very dangerous for persons with blood sugar-regulation problems. Anything we can do to keep our blood sugar level from climbing too high means a healthier future, as elevated blood sugar can lead to a significant increase in heart disease, kidney malfunction, eye problems and nerve disorders.<br /> <br /> With so many Americans suffering from type 2 diabetes and many more identified as pre-diabetic, now is the time to take control of weight, eating habits and exercise plan to support the body’s ability to keep blood sugar balanced. A healthy snack will enable consumers to achieve their lifestyle objectives.<br /> <br /> For a full list of references, visit<br /> <br /> Life Extension<br /> <br /> 3600 W. Commercial Blvd.<br /> Fort Lauderdale, FL 33309<br /> Phone: (888) 884-3657; (954) 766-8433<br /> Fax: (866) 866-8073<br /> Website:<br /> <br /> The Chlorogenic Acid From Green Coffee Bean Extract Promotes Weight Loss & Healthy Blood Sugar Levels<br /> <br /> Recent scientific evidence shows that high coffee consumption appears to reduce levels of blood glucose, increase insulin sensitivity, and decrease storage of fat and carbohydrate. And it has been confirmed that the blood sugar management benefits of coffee may stem from its weight-reducing effect.<br /> <br /> By analyzing combined data on more than 450,000 people, scientists have discovered that decaffeinated coffee provides the same protective effects as caffeinated coffee.1-5 So coffee’s ability to affect metabolism doesn’t stem from caffeine, but from a polyphenol called chlorogenic acid found in green coffee beans.<br /> <br /> It seems that chlorogenic acid inhibits both glucose absorption6 and the amylase enzyme that breaks down starch into sugar for absorption by the body.7 Chlorogenic acid helps facilitate glucose management by inhibiting weight gain, which it does by reducing glucose levels8 and decreasing intestinal calorie absorption.7,9 In addition to affecting glucose synthesis and release in the body10, chlorogenic acid reduces aftermeal blood glucose spikes that can last for hours or even a whole day.10 It also reduces body fat accumulation11, resulting in weight loss.<br /> <br /> To investigate chlorogenic acid’s weight-reducing effect, scientists used green coffee bean extracts since green coffee beans contain higher amounts of chlorogenic acid and other polyphenol compounds that are lost to a great degree during the roasting process.<br /> <br /> In a 12-week, placebocontrolled, human study, 30 overweight or obese volunteers took either green coffee bean extract or a placebo, dissolved in instant coffee. The extract produced an average 11-pound weight loss, a decrease in glucose absorption and an increase in glucose utilization. This decrease in glucose caused the body to metabolize stored body fat, which decreased the mass and amount of body fat.12<br /> <br /> In a subsequent 22-week crossover study, participants took 350 mg of green coffee bean extract three times a day for six weeks, 350 mg of green coffee bean extract twice a day for six weeks and a placebo for six weeks in a randomized, double-blind manner. In between each six-week phase, they took nothing for two weeks. They made no significant changes in their calorie intake or in the percentage of carbohydrates, fat and proteins they ate, and no significant change in exercise during the study. The green coffee bean extract was the only real difference. These were the results:9<br /> <br /> • Weight decreased over 17.6 pounds on average, with some participants losing more than 22.7 pounds<br /> <br /> • BMI (body mass index) decreased 2.92 on average<br /> <br /> • Body fat decreased 4.44 percent on average, with some participants losing 6.44 percent body fat<br /> <br /> • Heart rate decreased 2.56 beats per minute on average<br /> <br /> • 37 percent of the participants that were considered pre-obesity (25-30 BMI) returned to a normal-weight range9<br /> <br /> A follow-up to this study showed that, in contrast to food-restricted diets, 87.5 percent of the participants maintained their weight loss after the study9, with no side effects observed.<br /> <br /> Furthermore, in a recent study, 400 mg of green coffee bean extract was shown to suppress after meal glucose surges by 24 percent in just 30 minutes, while 200 mg was shown to suppress spikes by 14 percent in the same timeframe.13<br /> <br /> Chlorogenic acid inhibits excess activity of glucose-6-phosphatase, the enzyme that triggers glucose formation from protein and dietary fat, and glycogen release from the liver. It also targets the alpha-glucosidase intestinal enzyme, which breaks apart complex sugars and enhances their absorption into the bloodstream. It also increases the signal protein for insulin receptors in liver cells.<br /> <br /> Most beneficial polyphenols in coffee beans, especially chlorogenic acid, are destroyed during roasting. But for its 200 mg and 400 mg CoffeeGenic™ Green Coffee Extracts (GCA™), Life Extension used a patented extraction process from organically grown, green Arabica coffee beans. As a result, its GCA formulations are standardized to 50 percent chlorogenic acid to deliver greater weight-loss benefits and maximum support for maintaining healthy glucose levels already within normal range.<br /> <br /> Items #01620, 01604: These supplements should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.<br /> <br /> Caution: Because this product may lower glucose, those taking blood glucose lowering medication should consult with their health care provider before taking this product.<br /> <br /> CoffeeGenic™ contains GCA™, which is a registered trademark of Applied Food Sciences, Inc.<br /> <br /> * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.<br /> <br /> References: <br /> <br /> 1 Arch Intern Med. 2009 Dec 14;169(22):2053-63.<br /> <br /> 2 Int J Obes Relat Metab Disord. 2005;29:1121-9.<br /> <br /> 3 Diabetes Care. 2006;29:398-403.<br /> <br /> 4 Diabetes Care. 2005;28:1390-6.<br /> <br /> 5 Diabetologia. 2011 Feb;54(2):320-8.<br /> <br /> 6 Am J Clin Nutr. 2003;78:728-33.<br /> <br /> 7 J Agric Food Chem. 2009;57:9218-25.<br /> <br /> 8 N Engl J Med. 2006 August 24;355(8):763-78.<br /> <br /> 9 Diabetes Metab Syndr Obes. 2012;5:21-7.<br /> <br /> 10 Appl Physiol Nutr Metab. 2011 Oct;36(5):650-9.<br /> <br /> 11 Diabetologia. 2011 Feb;54(2):320-8.<br /> <br /> 12 J Int Med Res. 2007;35(6):900-8.<br /> <br /> 13 Nagendran MV. Effect of Green Coffee Bean Extract (GCE), High in Chlorogenic Acids, on Glucose Metabolism. Poster presentation number: 45-LB-P. Obesity 2011, the 29th Annual Scientific Meeting of the<br /> <br /> NaturaNectar LLC<br /> <br /> 1560 Sawgrass Corporate Pkwy., 4th Fl.<br /> Sunrise, FL 33323<br /> Phone: (800) 609-7794<br /> Websites:;;<br /> <br /> Aglycone Isoflavones: A More Efficient Natural Menopause Management<br /> <br /> First the Facts:<br /> <br /> • More than 43 million women in the U.S. alone are going through menopause.<br /> <br /> • Seventy-five percent of menopausal women experience hot flashes and or night sweats.<br /> <br /> • About a third of those have severe symptoms.<br /> <br /> • The findings from the Women’s Health Initiative over the last 10 years confirmed the risks of hormone replacement therapy (HRT).<br /> <br /> The Change<br /> <br /> When it comes to what women call “the change,” they know that being raised and living in the Western world, especially in America, is a great disadvantage. We are talking about the life changing period called menopause or the years before and after the date which marks 365 days past since a woman had her last period. These years are know as peri-menopause and postmenopause and are marked by a gradual decline in the women’s ability to produce sex hormones, especially estrogen. This gradual decline causes hormone cell receptors to send “hormone starvation” signals to the brain creating symptoms like hot flashes, night sweats, irritability and dryness of skin, to name a few. Asian women have been observed to be able to go through menopause, with far less discomforts than Western women.5,6 Research shows correlation between their diet—which is rich in legumes, especially soy—and the smaller incidence of menopausal symptoms.5,6 NaturaNectar’s decade-long research work on Brazilian Red Bee Propolis through its partnership with University of São Paulo, Brazil scientists, has identified this exotic type of bee propolis as being rich in aglycone isoflavones3, natural compounds used in EaseFemin.<br /> <br /> Isoflavones: Natural Alternative for Declining Hormones<br /> <br /> The daily intake of isoflavones have gained force as a viable natural alternative to HRT since 2002, when the first findings from the Women’s Health Initiative were published highlighting the health risks associated by the administration of hormone replacement therapies for menopausal women. Isoflavones are natural compounds that resemble the chemical structure of the hormone estrogen but still are not hormones. They bind well to the women’s hormone cell receptors and provide relief from their menopausal symptoms.*<br /> <br /> Glucosides x Aglycone Isoflavones<br /> <br /> However not all isoflavones are the same. EaseFemin only uses aglycone isoflavones. Scientific studies show that aglycone isoflavones are absorbed by the human body’s cell receptors in a more efficient and faster way than regular glucoside isoflavones4, those found in the vast majority of menopausal supplements in the market today. As a matter of fact, one study points that aglycone isoflavones intake were five times higher than the regular isoflavones.4*<br /> <br /> In EaseFemin, Aglycone Isoflavones are Combined From Two Sources<br /> <br /> The first is Isoƒactor™, NaturaNectar’s patent-protected, water-based extract from red bee propolis found only in the northeast of Brazil. The local bees naturally selected a native plant (Dalbergia ecastophyllum) to collect the resin needed for its production back in the beehives. NaturaNectar’s co-founder, Alessandro Esteves, discovered the botanical origin of this exotic propolis.1 Recent tests performed by Chromadex© Laboratories on Isoƒactor unveiled that besides being a rich source of aglycone isoflavones2,3, Isoƒactor has powerful antioxidant activity (ORAC = 3,540 Ìmol TE/g). This very compelling for women looking to get relief from menopausal symptoms while keeping their reproductive system young.* The second source is high quality not-genetically engineered fermented soy. Such unique combination of aglycone3 isoflavones are not present in any other product available today.<br /> <br /> Synergistic Calming Herbal Blend<br /> <br /> Given that mood swings and irritability are very common during menopause, EaseFemin added a proprietary calming herbal blend including valerian root, chamomile and passion flower. These herbs have been traditionally used for centuries not only for their calming effect, but for the observed synergistic effect on menopausal symptoms.<br /> <br /> * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.<br /> <br /> References:<br /> <br /> 1 Silva, B.B., Rosalen, P.L., Cury, J.A., Ikegaki, M., Souza, V.C., Esteves, A., and Alencar, S.M. Chemical Composition and Botanical Origin of Red Propolis, a New Type of Brazilian Propolis. Oxford Journals - Evidence-based Complementary and Alternative Medicine (2007) doi:10.1093/ecam/nem059.<br /> <br /> 2 Trusheva, B., Popova, M., Bankova, V., Simova, S., Marcucci, M.C., Miorin, P.L., Pasin, F.R., Tsvetkova, I. Bioactive Constituents of Brazilian Red Propolis. Oxford Journals - Evidence-based Complementary and Alternative Medicine (2006) doi:10.1093/ecam/nel006.<br /> <br /> 3 Alencar, S.M., Oldoni, T.L.C., Castro, M.L., Cabral,I. S.R., Costa-Neto, C.M.,Cury, J.A., Rosalen, P.L., Ikegakid, M. Chemical Composition and Biological Activity of a New Type of Brazilian Propolis: Red Propolis. ELSEVIER Journal of Ethno-Pharmacology, (2007) JEP-4694.<br /> <br /> 4 Izumi T, Piskula MK, Osawa S, Obata A, Tobe K, Saito M, Kataoka S, Kubota Y, Kikuchi M. Soy Isoflavone Aglycones Are Absorbed Faster and in Higher Amounts than their Glucosides in Humans. The Journal of Nutrition, (2000) 30(7):1695-9.<br /> <br /> 5 Boulet MJ, Odden BJ, Lehert P, Vemer HM, Visser A. Climacteric and menopause in seven southeast Asian countries. Maturitas, 1994;19: 157–76.<br /> <br /> 6 Notelovitz M. Estrogen replacement therapy indications, contraindications, and agent selection. Am. J. Obstet. Gynecol, 1989; 161: 8–17.<br /> <br /> Nordic Naturals<br /> <br /> 111 Jennings Dr.<br /> Watsonville, CA 95076<br /> Phone: (800) 662-2544<br /> E-mail:<br /> Website:<br /> <br /> Understanding Omega-3s and the Heart: New Research on Essential Fatty Acids, Inflammation and Cardiovascular Health<br /> <br /> In 1972, pioneering research on cardiovascular health and diet revealed a surprising relationship among a select group of people (Greenland Eskimo) who consumed large amounts of marine omega-3 polyunsaturated fats. Compared to their genetically similar counterparts in Europe, Greenland Eskimo had significantly lower incidences of coronary atherosclerosis. Since then, a compelling relationship has been put forth regarding the heart-health benefits of eating fish. Thousands of studies have sought to better understand this relationship and today this task continues. Despite remaining questions around omega-3s’ cardio-protective attributes, America’s leading health authorities recommend these essential fats for heart health: “The American Heart Association currently recommends one gram of [omega] ù-3 fatty acids daily (eicosapentanoic acid plus docosahexaenoic acid) for patients with established coronary heart disease.”<br /> <br /> As research on omega-3s’ benefits continues, one line of inquiry has turned to the role of inflammation in heart disease, and the ability of omega-3s to support the body’s natural anti-inflammatory response. A 2011 study considers the effects of omega- 3s on serum c-reactive protein (CRP) an important “marker for systematic inflammation [that] has been shown to be independently correlated with the presence of coronary artery disease, as well as the future likelihood of adverse cardiovascular events.” To date, there has been little attention in research focused on CRP and omega-3 essential fatty acids, but the study recently published in Clinical Lipidology points to the ability of omega-3s from fish oil to lower it, helping to further identify the potential mechanisms involved in the heart-health benefits of these essential fats.<br /> <br /> In the placebo-controlled study, 53 patients from the Cleveland Clinic, all with elevated baseline CRP concentrations, were randomly assigned to one of two groups: a treatment group which received three soft gels of omega-3 fish oil daily (Nordic Naturals® EPA, 425 mg EPA, 100 mg DHA per soft gel), or a placebo group. All patients in the groups were considered healthy and had a similar medical history. The study was double-blinded, so neither the participants nor the investigators knew the group assignments.<br /> <br /> After eight weeks of treatment, the study concluded. Results showed that while there was no statistically significant decrease in CRP from participants’ baseline levels, among the placebo group, reduction of CRP within the treatment group was substantial (-40.3 percent) and highly significant. The authors conclude that, “supplementation with omega-3 fatty acids— low-cost agents with few serious side effects or drug–drug interactions—may serve as an attractive complimentary modality for CRP reduction.” The one qualification they added is the somewhat limited predictive power of the relatively small study. As such, studies on larger samples are needed to help confirm their hypotheses.<br /> <br /> In light of these results, the current study lends support to the idea that it is the anti-inflammatory properties of omega-3 fats that confer many of its cardiovascular benefits. Moreover, the relatively low cost and good tolerability of high-quality omega-3 supplements is worth emphasizing, since conventional therapies are often far more expensive and less well tolerated in terms of overall health effects.<br /> <br /> Reference:<br /> <br /> Deepak L Bhatt, et al. Treatment with omega ù-3 fatty acids reduces serum C-reactive protein concentration. Clinical Lipidology 2011, 6(6):723–729.<br /> <br /> NOW Foods<br /> <br /> 395 S. Glen Ellyn Rd.<br /> Bloomingdale, IL 60108<br /> Phone: (800) 999-8069<br /> Fax: (800) 886-1045<br /> E-mail:<br /> <br /> Resolving Vitamin B12 Deficiency Using Oral Supplementation With NOW Foods Methyl B-12 5,000 mcg Lozenges<br /> <br /> Vitamin B12 (often referred to as cobalamin) is an essential nutrient that can only be obtained from diet or supplements. Cobalamin, in conjunction with folate, plays a critical role in DNA synthesis and neurological function. Cobalamin deficiency can therefore lead to a wide spectrum of blood related (e.g., macrocytic anemia) and neurologic symptoms (e.g., depression, memory loss, confusion and tingling in the extremities) that can be easily reversed by early diagnosis and treatment.<br /> <br /> The incidence of B12 deficiency appears to increase with age, with an estimated 15 percent of people over 65 having low serum cobalamin.1 Because the normal body stores of cobalamin are significant (2,000 to 5,000 mcg, mostly in the liver), it takes years to develop symptoms of deficiency. The signs are often non-specific and might be hard to recognize unless B12 levels are measured directly in the blood.2<br /> <br /> Because cobalamin absorption requires robust digestion and intact production of intrinsic factor (IF) in the stomach, the elderly are more likely to develop deficiency due to dwindling digestive function combined with limited consumption of meat (the main dietary source). Gastric juices enable extraction of cobalamin from food and IF binds with extracted cobalamin for further absorption in the small intestine. Eventually, body reserves of cobalamin are depleted and symptoms of deficiency emerge. Because dietary B12 is found almost exclusively in food of animal origin, vegetarians also have a significant risk of becoming cobalamin- depleted.<br /> <br /> After B12 Deficiency Diagnosis<br /> <br /> Traditionally, physicians have administered B12 injections to bypass the digestive tract, but current clinical research conducted with high-dose oral B12 supplementation challenges the traditional practice of injections.<br /> <br /> Since the discovery of its critical role in cobalamin absorption, the Ifdependent pathway has been understood to be the sole mechanism by which B12 can cross the gastrointestinal (GI) cell membrane. It is important to understand that IF allows for absorption of only up to 3 mcg of B12 from a single meal or supplement administration.3 Since the typical multivitamin contains only about 6 mcg, and absorption from this low dose has to rely on intact IF production, oral supplementation with a typical multivitamin is not an effective way to address B12 deficiency. In contrast, a single injection can deliver 1,000 mcg of vitamin B12, which is administered once a week at first, followed by a once a month regimen for the rest of the patient’s life.<br /> <br /> Fortunately, research has shown that B12 can be absorbed by “passive diffusion” without IF participation when administered in high doses.3 Although only about one percent of orally administered cobalamin crosses the GI cell membrane by this mechanism, the amount absorbed becomes significant as the dose of B12 increases. Because B12 has no known toxicity, very high doses can be given orally without safety concerns. Research shows that after administration of 10,000 mcg of cobalamin, about 100 mcg of B12 can be absorbed. A series of recent human bioavailability studies with 10,000 mcg B12 supports this conclusion (Unpublished, NOW Foods®, 2011-2012).<br /> <br /> Injections or Supplementation?<br /> <br /> The latest clinical confirmation of the effectiveness of oral vitamin B12 in the form of methylcobalamin lozenges, comes from a study conducted at ABC Wellness Clinic (Sterling Heights, MI) in collaboration with NOW Foods.4 In this clinical trial, 10 patients with newly diagnosed cobalamin deficiency were randomly assigned to receive either once-a-week B12 injections or daily high-dose 10,000 mcg methylcobalamin lozenge (NOW Methyl B-12, 5,000 mcg) for eight weeks. The study demonstrated that vitamin B12 lozenges were as effective as injections (see chart). All patients’ cobalamin and homocysteine levels returned to normal and their symptoms improved independent of the treatment group to which they belonged. The results strongly suggest that a high-dose daily lozenge regimen is a viable and convenient option.<br /> <br /> Additionally, lozenge supplementation offered a significant cost advantage as compared to injections ($35 for eight-week supplementation U.S. vs. $800 for eight-weeks of office-visit injections).<br /> <br /> For a full list of references, visit<br /> <br /> Nutrex Hawaii<br /> <br /> Kailua-Kona, HI 96740<br /> Phone: (800) 453-1187<br /> Fax: (808) 329-4533<br /> E-mail: • Website:<br /> <br /> Internal Sunscreen and Internal Beauty Pill: The Skin Health Benefits of Natural Astaxanthin<br /> <br /> Nicholas Perricone, MD, is probably the most famous dermatologist on the planet. He’s been on the New York Times (NYT) Bestseller list and has been on Oprah and countless other TV shows. Perricone thinks that natural astaxanthin is one of the best products one can take internally for their skin. He devoted three whole pages to Astaxanthin in his No. 1 NYT bestselling book The Perricone Promise. In fact, practically everywhere he goes, Perricone talks about natural astaxanthin— calling it a “superstar supplement” with the ability to reduce wrinkles and age spots.<br /> <br /> Some famous actresses and models must be listening to what Perricone thinks about astaxanthin. England’s second largest circulation newspaper, The Daily Mail, printed an article recently about how Gwyneth Paltrow and Heidi Klum use Hawaiian Natural Astaxanthin internally to help keep their skin looking healthy externally.<br /> <br /> And, of course, by now almost everyone in the natural products industry is aware that the Dr. Oz show featured a segment on astaxanthin last year. Dr. Joseph Mercola and Dr. Oz sat under a huge sign reading “The No. 1 supplement you’ve never heard of that you should be taking: Astaxanthin” and for five minutes talked about what a fantastic nutrient it is for a variety of conditions.<br /> <br /> Why are famous medical doctors and actresses buzzing about astaxanthin for skin health and its other benefits? Because there is already a volume of research showing that it works. Let’s look at the two most important human clinical trials to date on natural astaxanthin’s skin health benefits.<br /> <br /> In groundbreaking human clinical work for which a patent was awarded (U.S. Patent #6433025), Cyanotech Corporation funded a study at an independent consumer research laboratory to test the potential of Hawaiian Astaxanthin as an internal sunscreen. Twenty-one subjects were tested under a solar simulator, a machine designed to emit UVA and UVB ultraviolet radiation that mimics sunlight. Subjects’ skin was tested before supplementation began to see how much UV light was needed to cause burning. Then, subjects supplemented with 4 mg of natural astaxanthin daily for two weeks. After two weeks, the subjects once again underwent the sunburn test. The result: There was a statistically significant increase in the amount of time necessary for UV radiation to burn the skin. This result is particularly promising because astaxanthin has a cumulative effect in the body—it builds up in the organs over time. Two weeks is a relatively short time for the astaxanthin to concentrate in the body’s largest organ, the skin. Yet this study proved that in just two weeks natural astaxanthin was already working as an internal sunscreen.1,2<br /> <br /> The UV protective effect of astaxanthin is only one aspect of its benefits for the skin. Taken internally, astaxanthin can produce noticeable improvements to skin health and appearance externally.<br /> <br /> A clinical study in Japan demonstrated noticeable improvements in three important areas of skin health and appearance:3<br /> <br /> • Fine lines and wrinkles<br /> <br /> • Skin elasticity<br /> <br /> • Skin moisture levels This study was done on 49 middle aged female subjects. Subjects took placebo or 4 mg of natural astaxanthin per day for a total of six weeks. Skin parameters were compared at the beginning of the study and again at the end of the study. Results were measured using a variety of methods; whether measured by dermatological instruments, dermatologist inspection, selfassessment questionnaires or by beforeand- after photos, the results were all very positive: natural astaxanthin taken internally made these women more beautiful externally. It may be hard to believe for some people, but there is such a thing as an “Internal Beauty Pill.” A summary of the results include:<br /> <br /> • In the self-assessment (questionnaire), more than 50 percent of the subjects taking natural astaxanthin rated improvements in all areas<br /> <br /> • Dermatologist assessment found improvements in all areas tested (fine lines and wrinkles, elasticity and dryness)<br /> <br /> • Dermatological clinical instruments recorded improvements in both parameters tested (moisture content and elasticity)<br /> <br /> • Before-and-after photos showed visible improvements in fine lines, wrinkles and elasticity.<br /> <br /> It’s great to know that by taking natural astaxanthin internally, one is not only helping their eyes and brain, heart, joints and modulating the immune system, but they’re also taking an important step toward protecting their skin and making it look better from the inside out.<br /> <br /> For more information on astaxanthin’s documented health benefits, contact the authors at or visit<br /> <br /> References:<br /> <br /> 1 Lorenz, T. (2002). “Clinical Trial Indicates Sun Protection from BioAstin Supplement.” Cyanotech Technical Bulletin based on Independent Consumer Testing Company clinical trial. On file at Cyanotech Corporation.<br /> <br /> 2 Lorenz, T. “Method for Retarding and Preventing Sunburn by UV Light.” U.S. Patent #6,433,025. August 13, 2002.<br /> <br /> 3 Yamashita, E. “The Effects of a Dietary Supplement containing Astaxanthin on Skin Condition.” Carotenoid Science, Japanese Society for Carotenoid Research. Volume 10, 2006.<br /> <br /> Onnit Labs, LLC<br /> <br /> 2101 E. St. Elmo Rd., Ste. 320<br /> Austin, TX 78744<br /> Phone: (855) ONNIT-99<br /> E-mail: • Website:<br /> <br /> The Science of Alpha BRAIN<br /> <br /> Alpha BRAIN™, Onnit Labs’ flagship cognitive-enhancing supplement, contains nine natural, wellresearched compounds to create an effective and balanced nootropic. The formula’s ingredients are centered on three aspects of enhanced cognition: elevating levels of endogenous neurotransmitters, providing anti-stress compounds and promoting long-term neuroprotection.<br /> <br /> Boosting Neurotransmitters<br /> <br /> The human brain is comprised of more than 10 billion communicating cells, known as neurons, making more than 60 trillion synaptic connections.1 Neurotransmitters are the chemical messengers that embody the brain’s currency of communication. These connections give rise to complex neural circuits, which underlie the apparent phenomena of human cognition.<br /> <br /> Adequate functioning of neurotransmitter synthesis and release is essential to maintain a healthy cognitive state.2 Self-perceived states, such as attention, mood, focus and awareness, are highly dependent on the relative levels of neurotransmitter production. Alpha BRAIN aims to elevate the levels of the neurological production of neurotransmitters by providing an abundance of biological neurotransmitter precursors.<br /> <br /> Specifically, huperzine serrata and aGPC are targeted at increasing acetylcholine function, an essential component for learning and memory.3,4 L-theanine, a compound isolated from green tea, has been shown to mimic the important inhibitory effects of GABA neurotransmission, mediating a calm and focused mental state.5 L-tyrosine is a key intermediate in the biosynthesis of the neurotransmitters dopamine, epinephrine and norepinephrine with documented mood elevating properties.6<br /> <br /> Mitigating Stress<br /> <br /> Alpha BRAIN includes a combination of natural anti-stress compounds that have been shown to buffer the brain’s response to stress and provide an overall calming effect. Under the license from optigenex, Alpha BRAIN is the only nootropic to include AC-11®, a potent extract from Uncaria tomentosa. AC-11 has independently been proven to promote DNA repair following environmental stress and has documented cognitive benefits.7 Alpha BRAIN also includes highly concentrated oat straw (Avena sativa), an alleviator of exhaustion and neurological pain that has been shown to have a positive impact on cognitive performance in healthy subjects.8 Lastly, Alpha BRAIN contains phosphatidylserine, a phospholipid cell component known to possess ergogenic properties and promote stress tolerance in high performance athletes.9<br /> <br /> Targeting Neurological Antioxidants<br /> <br /> Oxidative stress, also known as free radical damage, has been implicated in a number of neurological diseases and age-related conditions.10 Alpha BRAIN includes antioxidative compounds that have been shown beneficial to cognitive function. Pterostilbene, a compound isolated from blueberries, has been shown to provide neuroprotection against free radicals.11 Bacopa monnieri has been used for centuries in the traditional ayurvedic medicine to improve memory and longevity, possessing both antioxidant and aptogenic effects.12 Research on bacopa has shown significant memory improvements and protection again the deposit of harmful neurotoxic molecules.13 Finally, the inclusion of vinpocetine, a semi-synthetic derivative of the periwinkle plant, promotes blood flow to the brain and possesses potent antioxidant properties.14<br /> <br /> Alpha BRAIN Delivers<br /> <br /> Alpha BRAIN’s highly effective ingredients are either cutting edge or have historical use. Supported by years of clinical research, each component in Alpha BRAIN includes the effective tested dosage. This combination aims to potentiate cognitive performance while maintaining mental clarity and longterm neurological health benefits.<br /> <br /> References: 1 Brancucci A. Neural correlates of cognitive ability. J Neurosci Res.<br /> <br /> 2 Crupi R, et al. New therapeutic strategy for mood disorders. Curr Med Chem, 18:4284-4298.<br /> <br /> 3 Orhan IE, et al. An overview on natural cholinesterase inhibitors–a multi-targeted drug class–and their mass production. Mini Rev Med Chem, 11:836-842.<br /> <br /> 4 Amenta F, et al. Association with the cholinergic precursor choline alphoscerate and the cholinesterase inhibitor rivastigmine: an approach for enhancing cholinergic neurotransmission. Mech Aging Dev, 2006, 127:173-179.<br /> <br /> 5 Song J, et al. Tea and cognitive health in late life: current evidence and future directions. J Nutr Health Aging, 16:31-34.<br /> <br /> 6 Mouret J, et al. [L-tyrosine cures, immediate and long term, dopamine-dependent depressions. Clinical and polygraphic studies]. C R Acad Sci III, 1988, 306:93-98.<br /> <br /> 7 Emanuel P, Scheinfeld N: A review of DNA repair and possible DNA-repair adjuvants and selected natural antioxidants. Dermatol Online J, 2007, 13:10.<br /> <br /> 8 Dimpfel W, et al. Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects. J Altern Complement Med, 17:427-434.<br /> <br /> 9 Starks MA, et al. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr, 2008, 5:11.<br /> <br /> 10 Ghosh N, et al. Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease. Free Radic Res, 45:888-905.<br /> <br /> 11 Chang J, et al. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer’s disease. Neurobiol Aging.<br /> <br /> 12 Stough C, et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebocontrolled randomized trial. Phytother Res, 2008, 22:1629-1634.<br /> <br /> 13 Shinomol GK, et al. Neuromodulatory Propensity of Bacopa monnieri Leaf Extract Against 3- Nitropropionic Acid-Induced Oxidative Stress: In Vitro and In Vivo Evidences. Neurotox Res.<br /> <br /> 14 Patyar S, et al. Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep, 63:618-628.<br /> <br /> Pharmachem Laboratories Inc.<br /> <br /> 265 Harrison Ave.<br /> Kearny, NJ 07032<br /> Phone: (800) 526-0609<br /> Fax: (201) 246-8105<br /> E-mail: • Website:<br /> <br /> Phase 2 White Kidney Bean Extract<br /> <br /> There are no studies or proof that a generic white kidney bean extract for weight and blood sugar management formulas works. Phase 2® White Kidney Bean Extract, however, does have solid research validating its efficacy in weight loss and blood sugar health.<br /> <br /> Historic Perspective<br /> <br /> The medical community has been interested in amylase inhibitors contained naturally in edible plant materials since the 1940s. From there, progress was swift. In the mid to latter 1980s, the Mayo Clinic sought to yield more clarified information from plant-based amylase inhibitors, and one study focused on a partially purified inhibitor, prepared by simple extraction of crude bean powder; it was shown to yield a much higher specific anti-amylase and less agglutinating activity when compared to other commercial preparations.<br /> <br /> This finding was the genesis of the development of what is now known as Phase 2 White Kidney Bean Extract. Phase 2 is a patented and highly concentrated extract made from a portion of the white kidney bean. It is made through a proprietary process that assures its potency and stability.<br /> <br /> The very first study of this proprietary white kidney bean extract was performed in 1999. This double-blind, placebo-controlled study of 40 overweight individuals showed that those who took a supplement containing Phase 2 several times a day for 12 weeks experienced statistically significant weight loss and BMI (body mass index) reduction. The Phase 2 supplement had a significantly greater effect on body weight than did the placebo (weight loss of 3.5 kg vs. 1.2 kg). In addition, body mass analyses show that the weight loss in the active group consisted mainly of fat loss as >85 percent of the weight loss was accounted for by fat.1<br /> <br /> Weight Loss<br /> <br /> Overall, 10 clinical studies have been performed on Phase 2 that have demonstrated weight loss over time. Three placebo-controlled studies of individuals who were either overweight or obese have shown significant loss of body weight with Phase 2 compared to the placebo. The doses ranged from 445 mg per day for four weeks to 3,000 mg per day for eight to 12 weeks.2 Another placebo-controlled study showed a comparative loss in body weight only when subjects were stratified by dietary carbohydrate intake. Those who consumed the greatest amount of carbohydrates lost significant body weight in comparison to the placebo group.2 Six additional studies reported a loss of weight over time, thereby validating efficacy of Phase 2. 2 Interestingly and of note, three clinical studies reported a reduction in serum cholesterol and triglycerides over time.2 Blood Sugar Health It appears that by preventing full absorption of dietary carbs to a significant degree will also confer a positive effect on blood sugar. Four crossover clinical studies addressed the potential effect of Phase 2 on post-prandial increases in blood sugar. All four studies indicated that Phase 2 could reduce post-prandial spikes in blood sugar with a suggestion that the effect is dose-related.<br /> <br /> For example, in one placebo-controlled, crossover study, 11 fasting individuals were given four slices of white bread and 42 g (3 tbsp.) Of margarine with or without 1,500 mg of Phase 2, added to the margarine. In comparison to control, the glucose levels following consumption of Phase 2 returned to baseline 20 minutes earlier. The area under the plasma glucose vs. time curve was 66 percent lower with Phase 2 compared to the control; indicated that one third of the carbohydrate in the bread was absorbed.2 In another study that used white bread with butter—with and without the addition of Phase 2 in capsule or powder form and in dosages of 1,500 mg, 2,000 mg and 3,000 mg—researchers found that the 3,000 mg dose caused a significant reduction (34.11 percent) in postprandial glucose levels.2<br /> <br /> Conclusion<br /> <br /> Experiments conducted with the Phase 2 alpha-amylase inhibitor indicate that it reduces the rate of absorption of carbohydrates, thereby reducing the glycemic index of foods, and promoting weight loss when taken with carbohydrate-containing meals. Reducing the post-prandial spikes of glucose and insulin following a high GI meal may also reduce the risks of developing insulin resistance, which can lead to cardiovascular disease.2<br /> <br /> References:<br /> <br /> 1 Dr. E. Thom, Parexel Medstat AS, Lillestrom, Norway, Journal of Int’l Medical Research, 2000; 28: 229-233.<br /> <br /> 2 Barrett M., Udani J.K., Nutrition Journal, 2011, 10:24 doi:10.1186/1475-2891-10-24<br /> <br /> Superior Source<br /> <br /> 4510 S. Boyle Ave.<br /> Vernon, CA 90058<br /> Phone: (800) 421-6175<br /> Fax: (323) 589-6667<br /> E-mail: • Website:<br /> <br /> Long Forgotten Super Hero—Vitamin B12!<br /> <br /> By Sally M. Pacholok, RN, BSN, and Jeffrey J. Stuart, DO, authors of Could It Be B12? An Epidemic of Misdiagnoses<br /> <br /> Vitamin B12 is essential for health and life. We need it for brain, nerve, blood, immune and cardiovascular function. A deficiency left untreated can slowly cripple or kill a person. The discovery of B12 won the Nobel Prize in Medicine in 1934, but today it is frequently overlooked by doctors and other health care providers, creating a reemerging epidemic. The classic signs and symptoms of B12 deficiency imitate a variety of other disorders and patients are frequently misdiagnosed. When this occurs, other costly medications, tests and treatments are prescribed. This misdiagnosis leads to medical malpractice and enormous health care costs, wasting billions of dollars.1-3<br /> <br /> Humans are unable to produce B12 and must obtain it from animal-based foods—or reliable high-dose vitamin supplements. B12 is not present in fruits, vegetables or grains. Therefore, vegetarians are at a higher risk for deficiency. However, eating animal products does not preclude one from deficiency.<br /> <br /> People become B12 deficient for three main reasons: 1) malabsorption, 2) diet, or 3) genetic defects. The No. 1 reason is malabsorption, where the body has difficulty absorbing B12 from food or certain types of vitamin supplements. B12 follows a complex pathway of several steps for proper absorption. A roadblock in any part of this pathway can cause malabsorption and subsequent deficiency. The stomach, small intestine, pancreas and liver all play vital roles in B12 absorption and delivery. There are a number of gastrointestinal disorders and surgeries that can cause faulty absorption. Some people have inherited conditions that do not allow them to process vitamin B12. Whatever the reason, the outcome can be equally catastrophic.<br /> <br /> B12 deficiency is reported to strike 48 million Americans, or 16 percent of the U. S. population.4 Approximately 15-25 percent of older adults are reported to have a B12 deficiency, but often times it is mistaken for symptoms of aging and other disorders.5 A deficiency can occur in any age group including infants whose mothers are deficient during pregnancy or breast feeding, making these children vulnerable for lifelong brain and/or nerve injury.6-7<br /> <br /> B12 must be present for the nervous system to produce myelin, the fatty protective covering that encases nerve fibers and axons. B12 deficiency damages this sheath, impairing the ability of nerve cells to carry messages. Without adequate B12, brain or nerve health suffers, causing an array of symptoms and dysfunctions.8 Parasthesias, neuropathy, difficulty with balance and gait, depression, foggy thinking, dementia, brain atrophy (shrinkage) and developmental delay are consequences of untreated B12 deficiency.9-10<br /> <br /> B12 deficiency is easy to prevent and treat, but its signs and symptoms are frequently overlooked. Deficiency develops slowly and symptoms appear gradually. It can easily be misdiagnosed as Alzheimer’s disease, depression, diabetic neuropathy, vertigo, Parkinson’s disease, mini-strokes, restless leg syndrome and mental illness. In younger people, the deficiency can be misdiagnosed as postpartum depression, fibromyalgia, chronic fatigue syndrome, multiple sclerosis and autism.<br /> <br /> B12 deficiency increases a patient’s risk for cardiovascular disease because it must be present for the conversion of homocysteine into methionine. A deficiency causes elevated homocysteine, which damages blood vessels—increasing the risk of heart attack, stroke and blood clots.11-12 People at risk for B12 deficiency include vegans, vegetarians, alcoholics, people with eating disorders, celiac and Crohn’s disease, autoimmune diseases, AIDS, liver disorders (i.e. cirrhosis, hepatitis C) and those who have had gastrointestinal surgeries (including gastric bypass). Certain drugs can cause or contribute to B12 deficiency including proton pump inhibitors (i.e. omerprazole), metformin (Glucophage) and the anesthetic nitrous oxide.<br /> <br /> Treatment is effective, cheap and free of side effects. There is a critical window of opportunity to treat, or permanent nerve damage may result. Symptomatic and at-risk patients should be tested prior to treatment. Injections and/or MicroLingual (underthe- tongue) B12 dissolvable tablets can effectively treat a B12 deficiency.<br /> <br /> After ingesting and absorbing B12, it must be converted into the active forms methyl-B12 and adenosyl-B12. Some people have difficulty converting B12 to the active forms due to genetic variations or liver disorders. Superior Source Vitamins has a product that offers both these active forms in one high-dose tablet, in a perfect delivery system—“No Shot Advanced B12.” This product dissolves on contact under the tongue, making active B12 immediately available for absorption. Superior Source MicroLingual technology instant release soft-molded tablets offer far superior absorption compared to compressed tablets or capsules, which contain many binders and fillers. For those who are B12 deficient, I recommend they get their B12 either through injection or MicroLingual technology.<br /> <br /> Through education and advocacy we can stop this epidemic in its tracks. B12 is the super hero for overall health, independence and longevity, and now Superior Source Vitamins delivers a super hero product—No Shot Advanced B12.<br /> <br /> For a full list of references, visit<br /> <br /> Wakunaga of America Co., Ltd.,<br /> <br /> 23501 Madero<br /> Mission Viejo, CA 92691<br /> Phone: (800) 421-2998 x114<br /> Fax: (949) 458-2764<br /> Website:<br /> <br /> The Science of Healthy Arteries: Kyolic 110 at the Forefront of Cardiovascular Health<br /> <br /> By Matthew Budoff, MD<br /> <br /> Cardiovascular disease is the No. 1 killer in America, causing nearly 25 percent of all deaths among both men and women.1 Although cardiac events are responsible for one in every four fatalities in the general population, firefighters are at an even greater risk. According to the National Fire Protection Association, the industry’s trade association, firefighters have a two- to four-fold higher risk of experiencing a cardiac event while on the job.2<br /> <br /> New findings from the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, however, show that a combination of Kyolic Aged Garlic Extract (AGE) and Coenzyme Q10 (CoQ10) can significantly reduce several key risk factors that contribute to this statistic.3 The double-blind, placebo-controlled study involved 65 middle-aged firefighters at moderate risk of heart disease. All the participants were examined prior to the start of the study. Each firefighter also underwent coronary artery calcium (CAC) scanning using Cardiac CT, a revolutionary imaging technology that accurately measures calcium deposits and plaque buildup in the arteries. CAC is one key measure of the burden of atherosclerosis in the cardiac arteries. C-reactive protein (CRP), a marker of internal inflammation that may contribute to a higher risk of heart attack, was also measured.<br /> <br /> Following evaluation, the firefighters were given either a placebo or a dose of Kyolic 110 containing 1,200 mg of AGE and 120 mg of CoQ10 daily for 12 months. At the end of the year, CAC and CRP were measured again. The UCLA researchers found that the firefighters taking Kyolic 110 had significantly less CAC in their arteries and lower CRP levels than those taking the placebo. After adjusting for age, gender, conventional cardiac risk factors and the use of statin drugs, Kyolic 110 was associated with a fourfold reduction in the progression of coronary artery calcification compared to the placebo. There was also a 7.7-fold reduction in CRP.<br /> <br /> Both AGE and CoQ10 may help modify a number of risk factors for atherosclerosis and cardiovascular disease. Earlier studies conducted at Harbor-UCLA Medical Center show that Kyolic AGE, combined with other nutrients, lowers blood pressure, improves oxidative biomarkers and enhances vascular function.4 Odorless and non-irritating, Kyolic AGE is made from 100 percent organically grown garlic that is aged in a special extraction process. This process creates compounds clinically shown to provide a number of beneficial health properties. CoQ10 is a powerful antioxidant that plays a key role in providing energy to cells. As such, it is vital to cardiovascular health. However, advancing age and the use of cholesterol-lowering statin drugs can reduce blood levels.5<br /> <br /> This current clinical trial, which illustrates the effect of Kyolic AGE and CoQ10 on arterial plaque buildup and other important risk factors in an established at-risk group of people, may also help the millions of ordinary Americans reduce their risk of a future heart attack. Adding a combination supplement containing these two nutrients could be particularly important for young to middle-aged adults since two out of every three people in the U.S. have some degree of plaque buildup in their arteries before age 55.6<br /> <br /> References: 1 Miniño AM, Murphy SL, Xu J, et al. Final data for 2008. National Vital Statistics Reports. Vol. 59(10). Hyattsville, MD: National Center for Health Statistics, 2011.<br /> <br /> 2 Fahy RF, LeBlanc PR, Molis JL. Firefighter Fatalities in the United States – 2011. National Fire Protection Association White Paper. NFPA Fire Analysis and Research, Quincy, MA. 2011.<br /> <br /> 3 Zeb I, Ahmadi N, Nasir K, et al. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. Journal of Cardiovascular Disease Research, 2012; 3(3):185-190.<br /> <br /> 4 Budoff MJ, Takasu J, Flores FR, et al. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Preventive Medicine, 2004;39(5):985-991.<br /> <br /> 5 Littarru GP, Langsjoen P. Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondroin, 2007;7 Suppl:S168-S174.<br /> <br /> 6 Strong JP, Malcom GT, McMahan CA, et al. Prevalence and extent of atherosclerosis in adolescents and young adults. Journal of the American Medical Association, 1999; 24;281(8):727-735.<br /> <br /> ZyCal Bioceuticals, Inc.<br /> <br /> 1565 Rte. 37 W., Ste. 6<br /> Toms River, NJ 08753<br /> Phone: (888) 779-9225<br /> Fax: (888) 779-9225<br /> E-mail: • Website:<br /> <br /> Bone Morphogenetic Proteins Offer an Answer to Bone and Joint Conditions<br /> <br /> Scientists have discovered new causes for bone and joint conditions, which calcium and vitamin D, nor glucosamine and chondroitin can fully address. New research points to the loss of key proteins which are responsible for activating stem cells to grow and maintain healthy bone and cartilage.<br /> <br /> Discoveries into the pathogenesis of bone and cartilage tissue loss now reveal that low levels of key, biologically active proteins are associated with diseases such as osteoporosis and arthritis. According to the National Osteoporosis Foundation, osteoporosis is the loss of both mineral and bone tissue. Vitamin- D, calcium and other minerals only address half of the problem as they do nothing to stimulate the production of new bone tissue, which is essential for calcium to bind and strengthen bone. Similarly, osteoarthritis is caused by the progressive breakdown and eventual loss of cartilage tissue in the joints. Glucosamine and chondroitin do not stimulate the production of new cartilage tissue, which is essential for them to work. The only proteins medically and clinically proven to activate stem cells, which grow bone and cartilage tissue, so these traditional supplement can work, are bone morphogenetic proteins (BMPs). Additionally, BMPs naturally protect against inflammation and the associated pain.1<br /> <br /> The BMP Discovery BMPs were first discovered at UCLA by an orthopedic surgeon, Dr. Marshall Urist, in 1964. Urist published his finding in the journal Science, which led to the birth of osteobiologics.<br /> <br /> Subsequent researchers showed that Urist’s discovery was a whole family of BMPs responsible for bone and cartilage growth, maintenance and repair (BMP-2 through BMP-10). In 1991, the first commercial application of Urist’s work was made available to orthopedic surgeons to grow bone and cartilage in spinal fusions as well as fracture healing— all with great clinical success and no side effects.2<br /> <br /> After nearly 20 years of commercial application of the full protein complex, scientists are now discovering the role of individual BMPs for bone and joint health, homeostasis and diseases. The American Journal of Clinical Nutrition published findings that BMP- 2 is missing or reduced in patients with osteoporosis.3 The Journal of Arthritis and Rheumatism reported, “The presence of BMP-6 in adult human articular cartilage indicates a functional role for this growth factor in the maintenance of joint integrity.”4 In the Journal of Arthritis Research and Therapy, new findings showed that “BMP-4 and BMP-5 are expressed in normal synovial tissue and were found decreased in osteoarthritis and rheumatoid arthritis.”5 In 2009, the Journal of Orthopedic Research published that “BMP-7 may be chondroprotective after traumatic injury in patients if it is administered within three to four weeks of the injury.”6 All of this recent research supports that all the BMPs are needed each day to keep our bones and joints healthy, and suggest their role in repair.<br /> <br /> Breakthrough Oral BMP Formulation<br /> <br /> In 2005, a team of scientific experts, doctors and business executives began working on a natural, orally delivered BMP-complex. Their work led to the launch of a new biologically active complex for bone and joint health, now known as Cyplexinol®. In 2007, ZyCal Bioceuticals, in compliance with FDA regulations, began manufacturing and marketing Ostinol™ Bone and Cartilage Stimulating Proteins—the first supplement to contain Cyplexinol, an oral BMP protein complex. Ostinol was first introduced to health care professionals, used by thousands of patients successfully.<br /> <br /> In 2012, ZyCal launched a consumer version of its successful professional products, which is now available through retailers, allowing consumers to get the benefits of Cyplexinol without a prescription or having to see a health care professional.<br /> <br /> References:<br /> <br /> 1 Di Chen, Ming Zhao and Gregory R. Mundy. Bone Morphogenetic Proteins (Volume 22, No. 4), 233-241.<br /> <br /> 2 Urist, MR Delange RJ Finerman GAM, Bone cell differentiation and growth factors. Science, 1983 220:680.<br /> <br /> 3 Gregory R. Mundy. Nutritional Modulators of bone remodeling during aging 1’2’3. American Journal of Clinical Nutrition, 2006.<br /> <br /> 4 K. Bobacz, R. Gruber, A. Soleiman, L. Erlacher, J. S. Smolen, and W.B. Graninger. Expression of Bone Morphogenetic Protein 6 in Healthy and Osteoarthritic Human Articular Chondrocytes and Stimulation of Matrix Synthesis In Vitro, Journal of Arthritis and Rheumatism, 2003, Vol. 48, No. 9, pp 2501-2508.<br /> <br /> 5 Carsten P Bramlage, Thomas Häupl, Christian Kaps, Ute Ungethüm, Veit Krenn, Axel Pruss, Gerhard A Müller, Frank Strutz and Gerd-R Burmester. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis, Journal of Arthritis Research and Therapy, 2006.<br /> <br /> 6 Mark Hurtig, Susan Chubinskaya, David C. Rueger, Jim Dickey. BMP-7 Protects against Progression of Cartilage Degeneration after Impact Injury, Journal of Orthopedic Research, 2009.

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