Vitamin Retailer May 2013 : Page 52

2013 Science of Supplements: Summer Issue his special section of Vitamin Retailer comes in response to the industry’s desire for more informa-tion—retailers wanting more infor-mation about the products they sell and manufacturers wanting to offer the science that backs the effectiveness of their prod-ucts. We have featured a similar section annually in Vitamin Retailer’ s sister publica-tion, Nutrition Industry Executive , since 2002, where it is designed to help manu-facturers gain a better understanding of the ingredients and services available that can make their products stand out. Vitamin Retailer is once again respond-ing to retailers’ increased demand for sci-ence and research by offering this section twice—first here in our May issue with our Summer installment, and then again in our November issue—providing companies with two opportunities to describe in some detail to you, our readers, the insight and research that goes into their products. Companies advertising in this issue of Vitamin Retailer have provided one-page reference articles to a) help our readers decide if they want to carry a product in their stores, or b) refer a customer to when they’re asking about the research behind a particular product. Manufacturers have responded to this opportunity with background information about the health concerns their products are intended to address, histories of the nutrients behind their products and details of research carried out on their products. We’ve also provided company addresses, phone numbers and website addresses to make obtaining additional information easier. T Following is an index of companies participating in the 2013 Science of Supplements: Summer Issue section: Barlean’s ........................................................................53 Bluebonnet Nutrition Corporation................................54 Doctor’s Best Vitamins ..................................................55 Enzymedica, Inc. ..........................................................56 Essential Formulas Incorporated ..................................57 Lifes2good ....................................................................58 MASQUELIER’s USA......................................................59 Mushroom Wisdom ......................................................60 Nature’s Plus..................................................................61 North Amer Herb & Spice ............................................62 NOW Foods ..................................................................63 Nutritional Magnesium Association ..............................64 Quincy Bioscience ........................................................65 SFI Natural Medicines USA Inc. ....................................66 SunDita..........................................................................67 Superior Source ............................................................68 Trace Minerals Research................................................69 .. truDERMA LLC ..............................................................70 Wakunaga of America Co., Ltd.....................................71 WWW.VITAMINRETAILER.COM s MAY 2013 52 VITAMIN RETAILER

Science Of Supplements: Summer Issue

This special section of Vitamin Retailer comes in response to the industry’s desire for more information— retailers wanting more information about the products they sell and manufacturers wanting to offer the science that backs the effectiveness of their products. nWe have featured a similar section annually in Vitamin Retailer’s sister publication, Nutrition Industry Executive, since 2002, where it is designed to help manufacturers gain a better understanding of the ingredients and services available that can make their products stand out.<br /> <br /> Vitamin Retailer is once again responding to retailers’ increased demand for science and research by offering this section twice—first here in our May issue with our Summer installment, and then again in our November issue—providing companies with two opportunities to describe in some detail to you, our readers, the insight and research that goes into their products. Companies advertising in this issue of Vitamin Retailer have provided one-page reference articles to a) help our readers decide if they want to carry a product in their stores, or b) refer a customer to when they’re asking about the research behind a particular product.Lion’s Mane Mushroom: Effective Brain Nutrient<br /> <br /> <br /> Manufacturers have responded to this opportunity with background information about the health concerns their products are intended to address, histories of the nutrients behind their products and details of research carried out on their products. We’ve also provided company addresses, phone numbers and website addresses to make obtaining additional information easier.<br /> <br /> U.S. Diet: A Dangerous Omega-3 to Omega-6 Imbalance<br /> <br /> These days more people complain of feeling tired and unhealthy. We are what we eat. But, day in and day out, most are ingesting foods our bodies are not designed to eat.<br /> <br /> There are more than one hundred trillion cells in our bodies. Each one reflects the balance of our diet. This balance is particularly important when it comes to the essential fats. <br /> <br /> Most of our Western diet has too much omega-6 and not enough omega- 3. Our ancestors ate natural green foods and the meat of free-roaming animals that also had eaten greens. This was a diet rich in omega-3.<br /> <br /> Today, industrialization of our food supply has led to a heavily processed, grain-based diet, for us and for the animals we eat. This is a diet rich in omega-6. The result is increased inflammation of our cells. Modern foods have dramatically altered the balance of omega-3 and omega-6 in all of our bodies, and it’s making us unhealthy. This imbalance causes inflammation and can be linked to cases of stress, obesity, diabetes, heart disease and some cancers.<br /> <br /> We’ve been bombarded with warnings about the consequences of our diet. Here is a simple message—excess inflammation is at the root of much that makes us ill. We need to reduce the omega-6 and increase the omega-3 in our diets.<br /> <br /> To that end, Barlean’s has introduced an easy solution.<br /> <br /> Ideal Omega-3 <br /> <br /> Just one capsule daily of Ideal Omega- 3 packs a high potency 1,000 mg of omega-3. One and done!<br /> <br /> Omega-3 essential fatty acids have been scientifically shown through various studies to nutritionally support the optimal structure and function of joint mobility1-4 and bone density, heart health5,6, healthy cholesterol levels7,8, blood glucose, energy and endurance, mental health9-11, visual acuity12 and more.<br /> <br /> Key points for Barlean’s new Ideal Omega-3 include:<br /> <br /> • Ideal Super-Concentrated Formulation: Delivers a proven, superconcentrated 1,030 mg omega-3 in a single fish gelatin soft gel.<br /> <br /> • Ideal Freshness & Purity: Derived from fish caught in the pristine, icy waters of Alaska. Recipient of the coveted 5-Star Rating from IFOS (the International Fish Oil Standards Program), an accredited third-party certification program.<br /> <br /> • Ideal Sustainability & Earth- Friendliness: Certified to rigorous Marine Stewardship Council (MSC) standards, which ensure that marine populations and ecosystems remain healthy for future generations.<br /> <br /> Ideal Omega-3 has been used in groundbreaking research in muscle physiology at Stirling University. Ideal Omega-3 is the only fish oil to be shown to be assimilated into muscle tissue in a time course study presented at ISSFAL (International Society for the Study of Fatty Acids and Lipids) in May 2012. 13 It is also the subject of further studies into muscle development, muscle strength in the elderly and performance in soccer players in a series of ongoing studies at both Stirling and Aberdeen University in Scotland.<br /> <br /> The work on Ideal Omega and muscle physiology has already proven to be important for designing training programs for top athletes using omega-3 as part of their regime. It also has implications for the general public who are using omega-3 supplements to improve their general health.<br /> <br /> Scan this QR code to watch a two-minute Ideal Omega-3 video.<br /> <br /> Omega Blood Count <br /> <br /> More people are becoming aware of omega fatty acids, but not really sure what their own body’s omega-3 and omega-6 ratio is. Now, a new simple test can answer this called Omega Blood Count.<br /> <br /> This advanced omega- 3 home blood test kit is simple and accurate. From a small pin-prick on the finger, a third-party laboratory measures the balance of omega-3 and omega-6 in the blood. Users will confidentially be sent their results along with the individual requirement of omega-3 needed to improve their health. It’s that simple.<br /> <br /> Each test kit contains:<br /> <br /> • 2 Finger prick sample devices<br /> <br /> • 1 blood collection card<br /> <br /> • 1 desiccant pouch<br /> <br /> • 1 storage bag<br /> <br /> • 1 instruction booklet<br /> <br /> • 1 return postage paid envelope <br /> <br /> Ongoing Ideal Omega Studies<br /> <br /> • Professor Kevin Tipton. Stirling University. Protein signaling—Effect of omega-3 on production of protein signalling molecule MTOR. Commenced October 2012 - completion date December 2013. <br /> <br /> • Dr. Stuart Galloway. Stirling University. Footballer Study—Primary outcomes impact of omega-3 on respiratory function, strength,speed and endurance in trained athletes. Commenced September 2012 - completion date May 2013. <br /> <br /> • Dr. Gray. Aberdeen University. Fish Oil and Sacropenia—Overcoming the blunted response to resistance exercise with fish oil to maximize musculoskeletal properties and functional abilities in older people. Commenced January 2013 - completion date January 2016.<br /> <br /> Future Ideal Omega Studies<br /> <br /> • Dr. Wittard. Stirling University. Omega-3 and weight control. Assessment of online weight control software using Ideal Omega-3. (awaiting funding; planned start date 2013).<br /> <br /> • Dr. Eyad. Kuwait University. Omega-3 and Diabetes—Impact of omega-3 supplementation in type 2 diabetes. (awaiting funding; planned start date 2013).<br /> <br /> For a full list of references, visit www.vitaminretailer.com.<br /> <br /> An Herbal Line With Quality at its Core<br /> <br /> Q: What is herbalism?<br /> <br /> A: Herbs to some extent can be viewed as chemical laboratories, since they provide many chemical compounds. Herbalism is the use of herbs or herbal products that consist of portions of plants or unpurified plant extracts containing several constituents, which often work together synergistically for their therapeutic or medicinal value.<br /> <br /> Q: Why do you think herbs have been used in all cultures throughout history?<br /> <br /> A: Humanity has always depended on plant resources for food, clothing, shelter and medicine to cure illness. Our ancestors were led by instinct, taste and experience to treat illness by using plants, animal parts and minerals that were not part of their usual diet. Primitive people learned by trial and error to distinguish useful plants with beneficial effects from those that were toxic or inactive, and also which combinations or processing methods had to be used to gain consistent and optimal results. In fact, many of today’s pharmaceutical drugs are derived from botanicals— they are essentially the grassroots of modern medicine.<br /> <br /> Q: What are the current trends for herbal consumption?<br /> <br /> A: There is a global shift toward the use of medicine of herbal origin, as the dangers and the shortcomings of modern medicine are growing more apparent. The market for botanicals has grown from a grassroots industry 40 years ago to a $3.6 billion retail value in 1997, and by 2015, the herbal market will grow to a $100 billion dollar industry. This is due in part to the current good manufacturing practices (cGMPs) and innovations, such as cleaner extraction methods and testing (e.g., HPLC, ICP-MS, TLC, UV-vis, and residual solvents, irradiation and pesticides, bolstering consumer confidence.<br /> <br /> Q: What have been the impediments to herbal products’ acceptance in the past?<br /> <br /> A: Though herbal products have become increasingly popular throughout the world, one of the impediments has been the lack of quality control. The quality of herbal extracts and the profile of the constituents in the final product have implications in efficacy and safety. The variability of the constituents in herbs or herbal preparations due to genetic, cultural and environmental factors (e.g., differences in growth, geographical location and time of harvesting) has made the use of herbal products challenging. For instance, the availability and quality of the raw materials are frequently problematic, the active principles are diverse and may be unknown, and quality of different batches of preparation may be difficult to control and ascertain.<br /> <br /> Q: What is the solution to those impediments?<br /> <br /> A: The cardinal responsibility of all manufacturers to ensure purity, safety, potency and efficacy. Bluebonnet rigidly follows various standards of quality for raw materials and finished products imposed through the cGMPs to ensure all herbal ingredients fulfill the basic requirements of being safe and effective. By providing standardized herbal ingredients, we use inherent characteristics, constant parameters, definitive qualitative and quantitative values that assure quality, efficacy, safety and reproducibility batch to batch. In fact, it should be known that standardization is a tool in the quality control process. The variability of the constituents in herbs or herbal preparations due to genetic, cultural and environmental factors has made the use of herbal medicines more challenging, and that is why Bluebonnet Nutrition is excited to introduce a fresh and innovative line of kosher, standardized herbal extracts.<br /> <br /> At Bluebonnet, we look at old herbs with fresh eyes. We look to science to ensure that we have identified the correct species and part of the plant that will provide the scientifically proven active constituent(s) that are responsible for that herb’s pharmacological benefit. Our goal in developing this line was to provide the industry with a broad assortment of top-selling, competitively priced, standardized herbal extracts (and in some cases, concentrates) that are as wholesome as the herbs from which they were derived, ensuring that every serving is safe and efficacious through its expiration date. All of Bluebonnet’s standardized herbal extracts are derived from the purest herbs the Earth has to offer (sustainably wild-crafted or harvested), manufactured without using any harmful solvents or irradiation, and encapsulated in vegetable-derived capsules for immediate absorption and optimal bioavailability, providing a line of kosher-certified, standardized herbal extracts that are truly vegetarian from the inside out.<br /> <br /> Scientific Support & Differentiating Factors of Best Brain Magnesium<br /> <br /> Best Brain Magnesium features the proprietary Magtein™ magnesium- L-threonate (MgT), a compound of magnesium, which is a dietarily essential mineral. Magnesium from MgT was found in an animal model to be better absorbed when directly compared against magnesium chloride, magnesium glycinate and magnesium citrate.1 MgT is also well tolerated, in contrast to the gastrointestinal side effects that can occur with other forms of magnesium supplementation.2 MgT is a magnesium salt of L-threonic acid, a normal metabolic constituent found in the human body—most likely as a breakdown product of vitamin C.3 <br /> <br /> Magnesium is involved in more than 300 metabolic actions as an enzyme cofactor, and helps to maintain cardiovascular health, normal muscle and nerve function, a steady heartbeat, strong bones, blood sugar and energy metabolism and a healthy immune system. 4 Lesser known are its contributions towards cognitive and brain health.<br /> <br /> • Unique Magnesium Delivery Into the Brain. The MgT in Best Brain Magnesium has been shown to effectively raise magnesium levels in the brain, according to animal research carried out with MgT.<br /> <br /> • Supports Memory & Learning.<br /> <br /> Dietary intake of magnesium is known to affect learning and memory. One interesting example is a study of Taiwanese adolescent girls.5 Hair samples from 148 female students were analyzed as a method of determining consumption of trace elements; the data showed that higher learning performance (as measured by academic records of the students) was associated with higher magnesium and zinc levels in their hair.<br /> <br /> The brain’s hippocampus region is known to be essential for memory and learning processes. Aging-related decline in memory and learning capacity of the hippocampus may be related to a magnesium deficit.6<br /> <br /> • Promotes Stability & Adaptability of Synapses. Magnesium is a cofactor for numerous enzymes that control nerve cell functions and synapse integrity. Synapses are the points where nerve cells make close contact with each other via their cell membranes to exchange information. The movements of ions such as Mg2+ across the nerve cell membranes can change as we age, adversely affecting cellular excitability, chemical transmitter release and synaptic plasticity (synapse adaptability).<br /> <br /> The ability to store new information in nerve cell networks depends on the density and strength of the synapses, and their capacity to adapt to changing information inputs (synaptic plasticity). Additionally, loss of synapse density is correlated with age-dependent memory decline in rats. Numerous animal trials have been performed to measure the effect of MgT on cognitive outcomes. In a recent investigation, feeding MgT to raise brain magnesium led to significant enhancement of spatial and associative memory in both young and old rats.1 From the results of this study, which also incorporated experiments with cultured nerve cells, the researchers concluded that increasing the concentrations of brain magnesium induces permanent enhancement of synaptic plasticity in networks of hippocampal neurons.<br /> <br /> Fear is a basic survival mechanism that in modern times often causes more distress than is useful to us. Progress has been made in understanding the plasticity of brain circuits involved in lessening fear (“fear extinction”), and how magnesium—particularly MgT—can be a part of the process. In a 2011 study, Magtein was administered to rats for four weeks to elevate brain magnesium either before or after fear exposure.7 When given before fear extinction learning, Magtein enhanced the retention of fear extinction without altering the original fear memory (this is usually considered beneficial; fear extinction is the lessening of a conditioned fear response). The researchers had previously demonstrated that it took about two weeks to elevate brain magnesium levels and enhance memory by MgT.<br /> <br /> Memory and learning decline with age, yet MgT has been shown to slow this decline in mice.8 At the cellular level, MgT supported the integrity of synapses in the hippocampus, frontal cortex, and other regions of the brain. MgT hasn’t yet completed a clinical trial, but human studies have evaluated the effects of magnesium on human memory performance. For example, in a study of 71 men and women higher blood levels of magnesium were associated with superior cognitive function, as measured by clinical ratings and scales.9<br /> <br /> ATPro: A New Groundbreaking Technology<br /> <br /> ATP (adenosine triphosphate) is the body’s energy currency. Produced by cells of all living organisms, ATP acts as a battery, supplying cells with the energy needed for the whole body to be vital and alive. In the gastrointestinal (GI) tract, ATP plays a key role in signaling timely, proper and complete digestion of food, in part by regulating gastric acid (HCl) and pepsin secretion (a protein-digesting enzyme).1,2 It is also vital in <br /> the absorption of nutrients through the cell wall.<br /> <br /> ATP allows us to get the most benefit from the foods we eat. The average raw meal, such as a tossed salad, contains 300 million LCUs of ATP. Because our cells manufacture ATP from nutrients in the foods we consume, we reduce the demand when ATP is naturally present in a raw meal. When the balance of cellular energy is compromised, it leads to less efficient absorption and utilization of nutrients. This contributes to less energy output from cells, and even lower levels of digestive enzymes.<br /> <br /> “Raw foods contain an abundance of ATP along with the nutrients that enable efficient energy production,” said Walter Crinnion, ND‡, professor and chair of the Environmental Medicine Department at Southwest College of Naturopathic Medicine, and author of Clean, Green & Lean. “The problem is that the average American diet—overcooked and processed—is largely devoid of ATP and enzymes, which leaves us in a constant state of energy deficiency.” The common effects include fatigue, hunger, digestive distress and low hydrochloric acid (HCl).<br /> <br /> A combination of aging, exercise and eating cooked and processed foods can significantly increase the demand to produce large amounts of ATP2, thus making it difficult for the body to keep up. As a consequence, even those living a relatively healthy lifestyle may be challenged with a constant state of energy deficiency. A digestive supplement providing ATP and enhancing ATP production may help offset such a deficiency.* <br /> <br /> Digest Gold With ATPro <br /> <br /> In April 2013, Enzymedica announced that ATPro™ technology, a blend of critical nutrients that provide ATP and enhance ATP production, will now be part of the company’s flagship Digest Gold™—the most potent and No. 1- selling digestive enzyme product in the market.† Digest Gold comprises high potency protease, lipase, amylase and cellulase enzymes to support protein, fat, carbohydrate and fiber digestion.* ATPro technology is a proprietary combination of ATP, CoQ10, magnesium citrate and alpha lipoic acid, to promote nutrient absorption, improve Hcl availability and decrease the energy demand of digestive process.* Enzymedica’s Digest Gold now contains 300 million LCUs of ATP per capsule.<br /> <br /> Magnesium citrate is a coordinating ion for ATP. ATP must be bound to a magnesium ion in order to be biologically active. What is called ATP is often actually Mg-ATP. The antioxidant alpha lipoic acid plays multiple roles as a cofactor in the energy-generating Krebs cycle, which produces ATP. CoQ10 helps shuttle around energy-carrying electrons to maximize ATP production.<br /> <br /> According to Crinnion, ATPro added to Digest Gold optimizes digestive power by regulating the production of Hcl in the digestive tract.* Each capsule provides 300 million units of ATP, equivalent to levels of ATP found in a raw salad. The product also helps to maintain the integrity of the lining of the GI tract to support peristalsis and regularity.* <br /> <br /> Combining a full spectrum of digestive enzymes with ATPro, Digest Gold offers unsurpassed digestive support— the most potent digestive enzyme formula on the market. Digest Gold with ATPro is available in health food stores nationwide and online.<br /> <br /> † Digest™ and Digest Gold™ are the two top-selling digestive enzymes on the U.S. market according to SPINS, a market research and consulting firm for the Natural Products Industry.<br /> <br /> ‡ Walter Crinnion, ND is a compensated medical advisor to Enzymedica.<br /> <br /> * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.<br /> <br /> The Effect of Probiotic, Dr. Ohhira OMX Capsules, in the Treatment of<br /> Acute Non-bloody Diarrhea in Infants 3-24 Months of Age<br /> <br /> The term “probiotic” was first used to describe live microbial supplements, which beneficially affect the host upon ingestion by improving the balance of the intestinal microflora. Probiotic bacteria favorably alter the intestinal microflora balance, inhibit the growth of harmful bacteria, promote good digestion, boost immune function and increase resistance to infection. Their therapeutic use in diarrhea seems to be impressive. A number of agents have been isolated and studied with a view to clinical use. However, doctors are still reluctant to use these agents in clinical practice.<br /> <br /> Objective <br /> <br /> To determine the safety and efficacy of probiotics, Ohhira OMX* (Dr. Ohhira’s Probiotic) capsules, in the treatment of acute non-bloody diarrhea in patients 3- 24 months of age.<br /> <br /> Design & Setting <br /> <br /> Randomized clinical trial in a government secondary hospital.<br /> <br /> Subjects <br /> <br /> Seventy infants 3-24 months of age with acute non-bloody diarrhea, with no to some dehydration, with no other concomitant illness and without any previous antimicrobial therapy: 35 (mean +/- SD age 13.47 +/- 7.28 months) in the intervention group and 35 (mean +/- SD age 11.54 +/- 5.91 months) in the control group.<br /> <br /> Methods <br /> <br /> From January 1 to March 31, 2005, subjects enrolled were given either oral rehydration salts (ORS) or ORS with Ohhira OMX probiotics, one capsule twice a day for five days. The frequency, consistency and duration of diarrhea were then recorded in each group. Ttests, Mann Whitney U tests, Chi-square tests and Fischer Exact tests were used in the analysis of the different variables of both groups. P value <0.05 was considered significant.<br /> <br /> Main Outcome Measures <br /> <br /> Number of days with diarrhea, decrease in the frequency of stool and change in the consistency of stool.<br /> <br /> Secondary Outcome Measures <br /> <br /> Weight gain, weight loss, recurrence of dehydration, occurrence of other diseases, occurrence of bloody diarrhea and unplanned need for IVF.<br /> <br /> Results <br /> <br /> Infants in the probiotics group had a shortened duration of diarrhea and decreased frequency of stools per day. The mean (SD) duration of diarrhea among patients in the control group was 5.42 (+/- 1.72) compared to those given with Ohhira OMX probiotics who had a mean (SD) duration of 3.17 (+/- 1. 34) (p value = 0.000001). Thirty-four (97. 13 percent) infants given probiotics had weight gain (mean (SD) 0.35(+/- 0. 14) kg) while 27 (77.1 percent) infants in the control group had weight gain (mean (SD) 0.25(+/-0.13) kg) (p value = <0.01). Recurrence of diarrhea, occurrence of other diseases and occurrence of bloody diarrhea nor unplanned need for IVF were not observed in both sets of patients. Both sets of patients did not manifest any adverse reactions.<br /> <br /> Conclusion <br /> <br /> The use of probiotics significantly affects the duration of diarrhea: the mean days were shorter (3.17 days) in the probiotic group than in the non-probiotic group (5.42 days). Its use also produced no adverse effects. The routine use of Ohhira OMX probiotic capsules as preventive agents remains to be proven and further trial is recommended.<br /> <br /> Taking Dietary Supplements Generates Healthier Hair Growth<br /> <br /> Clinical trials and an increasingly extensive body of anecdotal evidence suggest a causal relationship in taking nutritional supplements and strengthening hair, halting hair loss and even re-growing hair. Hair growth supplements help to keep the body healthier, provide essential nutrients for building complex proteins and ignite metabolism to increase the intervals of anagen hair growth. A double-blind clinical study by Dr. Glynis Ablon showed significant hair growth after 90 days and 180 days for participants who took proprietary nutritional supplements during the scientific study.<br /> <br /> The subjects of the clinical trial were women between the ages of 21 and 75, women who were generally healthy but complained of thinning hair. The trial included people with alopecia or hair loss.<br /> <br /> Ablon chose women for her study because she had developed the hypothesis that many women, concerned with their physical appearances, were failing to get adequate nutrition from fad diets that sacrifice essential nutrients to generate weight loss. The study required that participants maintain their normal diets, medications, shampooing frequencies and hair length, and follow their usual daily routines so that the results could be scientifically attributed to the only common variable—taking nutritional supplements or receiving placebos.<br /> <br /> Subjects of the trial included women of various skin types, according to the Fitzpatrick classification of types I-IV. Women with food allergies, pregnant women and women who planned to become pregnant were excluded. Women of childbearing years agreed to accept birth-control medication to prevent any accelerated hair growth or thinning hair due to hormonal changes that occur during pregnancy. Everyone received either supplements or placebos in the double-blind study.<br /> <br /> Chemical Composition of Hair <br /> <br /> Hair consists of keratin, a complex protein that protects skin and causes toenails and fingernails to grow. Hair has a complex, three-layered structure that includes the cuticle, medulla and cortex. The cuticle, the colorless outer layer, protects the cortex, which contains the melanin that generates color in hair. Lack of melanin produces blond, gray and white hair. The complex structures of hair shafts need to receive nutrients from the blood to survive and grow, so nutrition affects hair growth in the following ways:<br /> <br /> • During the anagen phase of growth, cells in the papilla of the scalp divide and form the hair shaft.<br /> <br /> • The shaft becomes keratinized as it pushes its way past hair follicles.<br /> <br /> • Simultaneously, follicle roots grow deeper into the scalp to connect with nutrients from the blood.<br /> <br /> • Nutrients make the scalp structures healthier, supply the materials for building complex proteins and stimulate metabolism to increase intervals of sustained anagen growth.<br /> <br /> Ablon’s Clinical Hair Growth Trial <br /> <br /> Control-treated subjects had remarkably different results from those who received placebos. The treated group reported thicker hair, better moisture retention, brighter shine and better skin. No adverse effects of any kind were reported by people who took the supplements. Quantifiable results included the following:<br /> <br /> • Terminal hairs, three-layered hair on the scalp and other parts of the body increased by 125 percent after six months in treated subjects.<br /> <br /> • Vellus hair, the fine, two-layered hair that covers the body, remained unchanged in both groups.<br /> <br /> Diet & Nutrition Play Crucial Roles in Hair Health <br /> <br /> The study’s results proved conclusive in supporting Ablon’s premise. Recognized authorities from the National Institute of Health and Mayo Clinic recognize that good nutrition helps to stop hair loss, but these respected sources recommend that people get their nutrients by eating proper diets. Unfortunately, many people have trouble eating balanced meals, so taking supplements offers an alternative for people who live busy lifestyles, have stressful careers or follow special diets. Hair growth supplements not only strengthen hair and stimulate regrowth, but also deliver proprietary nutrient packages for overall health and wellness.<br /> <br /> Viviscal Dietary Supplements & Hair Health<br /> <br /> Viviscal supplements include AminoMar C™ Marine Complex, magnesium stearate, horsetail extract, vitamin C and hydroxypropyl methylcellulose. Several rigorous eight-month and 12-month scientific studies have demonstrated that supplements prove efficacious in halting and reversing hair loss. About 75 percent of Viviscal users in one study reported stronger hair, less breakage and new growth. The study conducted by Ablon has demonstrated similar results for women, which shows a clear cause-and-effect relationship from taking supplements and growing healthy hair.<br /> <br /> Vascular Health From France: Dr. Masquelier’s OPCs<br /> <br /> On April 1, 1969, the U.S. Patent Office granted Dr. Jack Masquelier and scientific colleagues U. S. Patent 3,436,4071 concerning the extraction and application of a group of substances first known as “leucoanthocyans,” from the bark of the Pinus maritima tree, particular to Southwest France. A year earlier, this pine bark extract became available as Flavan® and remains a classic herbal remedy2 on the French market. Known as MASQUELIER’s® French Pine Bark extract outside France, the extract’s composition and vascular health benefits remain unchanged today.<br /> <br /> Masquelier’s invention of “pine bark extract” took place when scientists were looking for a compound informally named “vitamin P” (P for healthy permeability of blood vessels). His invention related to a new compound he identified as “an active element of a bioflavonoid or vitamin P factor, which is effective in the treatment of venous, vascular, and capillary diseases. […] <br /> <br /> “Numerous pathological states are known to be characterized by capillary fragility: decreasing resistance produces spontaneous hemorrhages, while increasing permeability allows the formation of edemas.” The “leucocyanins” in MASQUELIER’s French Pine Bark extract are this “vascular permeability factor.” <br /> <br /> As Masquelier’s research progressed, “leucocyans” became “oligomeric proanthocyanidins” or “OPCs.” In 1970, Masquelier developed another patented method to isolate OPCs, this time from the seeds of Vitis vinifera, which in turn became another classic herbal remedy for vascular health. The clinical research begun in the 1970s focused on diverse conditions that have decreased capillary resistance in common3: cirrhosis of the liver4, venous problems in the legs and varicose veins5, diabetic retinopathy6, premenstrual syndrome7 and sports injuries.8 <br /> <br /> Masquelier continued studying his OPCs, focusing on the underlying physiological actions and health benefits. In several in-vitro studies, its antioxidative effects, such as the inhibition of LDL oxidation, were confirmed. The most recent essentially supportive scientific research is a randomized controlled clinical study performed with MASQUELIER’s Original OPCs at the University of Maastricht (Holland).9 <br /> <br /> The study confirmed the long-standing and diverse vascular benefits of MASQUELIER’s OPCs. After eight weeks of supplementation, a significant decrease in serum total cholesterol and LDL was observed. Additionally, the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22 percent in the supplemented subjects. The researchers also observed anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and a significant reduction of the expression of inflammatory genes in leukocytes. Not all changes in the measured biomarkers reached statistical significance, but, it was concluded that “integrating all measured effects into a global, so-called vascular health index, MASQUELIER’s Original OPCs “revealed a significant improvement of overall vascular health by compared to placebo.”<br /> <br /> Lion’s Mane Mushroom: Effective Brain Nutrient<br /> <br /> Lion’s Mane (Hericium erinaceus) is quite distinctive. First, it looks unlike any other traditional mushroom, as it grows often on trees, protruding voluptuously and covered with long white fronds, akin to a lion’s mane. Second, its naturally occurring constituents have been shown by research to have an affinity for supporting the healthy function and structure of the brain.<br /> <br /> Dementia and Alzheimer’s disease (AD) are two conditions feared by many. Yet, in today’s modern, fast-paced world, lifestyles create disruptions in our attention, as well as a low-grade chaos of thoughts that tend to increase stress on the brain, which may impact certain neurochemicals and proteins, such as nerve growth factor (NGF).<br /> <br /> NGF is part of a family of neurotrophic proteins that play key roles in maintenance, survival and regeneration of neurons. With aging, NGF levels decline, resulting in less efficient brain functioning and repair. Mouse studies have correlated such decline with AD-like conditions. NGF has been found to play a critical role in maintaining healthy cognitive function.<br /> <br /> A relationship between changes in NGF levels and anxious behaviors has been observed in humans. One study showed that soldiers experiencing their first parachute jump exhibited increased NGF levels, implying that the stress triggered the release of NGF into their systems. 1 There is also evidence that NGF levels rise during the initial stages of romance, and feeling “in love.” After these feelings subside, so too do NGF levels.2 <br /> <br /> Additionally, many clinical trials have shown that NGF can reduce neurodegeneration and has the potential to treat diseases of the central nervous system (CNS). Changes in NGF levels in the CNS also appear to impact neurodegenerative disorders such as AD.3 <br /> <br /> Since the discovery of NGF, researchers have been interested in ways of enhancing amounts of it in the body. But NGF is unable to cross the bloodbrain barrier so it cannot be administered orally. Therefore, researchers have been trying to find bioactive compounds with a low molecular weight that could penetrate the blood-brain barrier and be taken orally to induce synthesis of NGF within the brain.<br /> <br /> One researcher, Hirokazu Kawagishi, PhD, discovered a class of active compounds in Lion’s Mane mushroom that stimulate NGF production, influencing regrowth and repair of neurons.4 These compounds, hericenones, are the first active substances found in natural products to induce NGF synthesis. Kawagishi isolated hericenones from the fruiting body of Lion’s Mane and introduced it into a culture containing rat astroglial cells. After 24 hours an assay revealed that NGF was secreted into the culture medium.<br /> <br /> Further, Lion’s Mane also contains a compound that helps preserve brain structure and function in another manner. Amyloid beta-peptide is the main component of plaque that develops in the brains of AD patients. As the plaque grows it destroys neurons and neuronal death is a hallmark of neurodegenerative diseases. Also, it is believed that amyloid plaque accumulation likewise increases risk of cerebral hemorrhagic stroke as it causes blood vessels to become brittle and eventually break.<br /> <br /> Amyloban is a fat-soluble fraction found in Lion’s Mane, and it was found to protect against neuronal cell death caused by amyloid beta-peptide, which is also a chief catalyst of cellular stress and neuron damage.5 In assays of rat cell viability, researchers found that amyloban protects neurons from endoplasmic reticulum (ER) stressor oxidative stressdependent cell death associated with amyloid beta peptide. <br /> <br /> Finally, more extensive screening of Lion’s Mane constituents yielded three new active compounds. One, 3-hydroxyhercenone, showed significant protective activity against chemically induced ER stress in neuronal cells.6 <br /> <br /> It is important to know that not all Lion’s Mane mushroom supplements contain viable amounts of amyloban and hericenones—because these two compounds are fat-soluble, those Lion’s Mane products extracted solely by hot water will not have them in the final supplement product. Also, as these compounds are abundant in the fruiting body of Lion’s Mane, there is no evidence to suggest that the mushroom’s mycelium contain either hericenones or show bioactivity similar to that of amyloban. The method to concentrate active compounds, which requires ethanol extraction and some fractionations called Amycenone™, has been filed for a U.S. Patent. This is the extract found in the product Amyloban® 3399 (a designation from the Japanese patent number).<br /> <br /> For the millions of Americans seeking to maintain healthy brain structure and function, Lion’s Mane mushroom can provide nutrients that help preserve stores of NGF, a neurotrophic protein that, when in healthy supply, helps ensure healthy cognition.<br /> <br /> The New Revolution in Anti-Aging Antioxidant Science<br /> <br /> It often takes decades for the public to catch up with the latest research. For example, early studies in the 1960s and 70s showed that high-fat diets were strongly associated with heart disease. By the early 1980s, many people were avoiding all dietary fats. But by the mid- 80s, scientists came to understand that not all fats are alike; in fact, unsaturated fats and essential fatty acids (EFAs) promote heart health. Yet, for decades people continued avoiding healthy fats.<br /> <br /> A similar situation occurred with probiotics. For many years, people viewed all microorganisms as pathogens, and avoided even the good microorganisms in yogurts, pickles and relishes. Today, they are widely known as probiotics. Again, many avoided their benefits for decades, simply due to a lack of knowledge. As with other poorly understood nutrients, the general population now suffers from a lack of understanding of antioxidants.<br /> <br /> Nature’s Plus seeks to empower consumers with a new understanding in its new line of 23 AgeLoss supplements. The revolutionary new understanding can be exemplified in the science of a key ingredient, olive fruit/leaf hydroxytyrosol. Researchers and health experts have already adopted a new way of looking at antioxidants and free radicals. The old understanding held that one antioxidant is essentially the same as another. The new understanding is that there are five major classes of free radicals, each with unique characteristics and thus affecting different tissues very differently.<br /> <br /> Each tissue and cell is continually under attack by a unique combination of these classes of free radicals; peroxyl, hydroxyl, peroxynitrite, superoxide anion and singlet oxygen free radicals. Battling these free radicals are five major classes of whole food antioxidants activities: ORAC (anti-peroxyl), HORAC (anti-hydroxyl), NORAC (antiperoxynitrite), SORAC (anti-superoxide) and SOAC (anti-singlet oxygen). The term “Total ORAC” is the sum of all five classes of activity.<br /> <br /> Under the old way of thinking, one might expect that 1,000 Total ORAC units of vitamin C activity daily would work just as well against artery-clogging free radicals as 1,000 Total ORAC units of antioxidant activity from any other nutrient; for example olive hydroxytyrosol. But this equivalency has been proven invalid. A simple comparison of search results through the National Library of Medicine’s online PubMed database shows that researchers are focusing more on the artery-clogging activity of the superoxide anion than any other free radical. Research on the damages caused by the hydroxyl free radical comes in second. The remaining free radicals receive relatively little attention.<br /> <br /> As such, one would expect that fatsoluble hydroxytyrosol, with stronger SORAC and HORAC activity, would be more effective than vitamin C, which is not fat soluble, and has substantially lower SORAC and HORAC activity. Vitamin C reportedly has approximately 3,000 Total ORAC µmole TE/g directed primarily against the superoxide anion, with relatively little HORAC activity.<br /> <br /> Olive fruit/leaf hydroxytyrosol, on the other hand, is fat-soluble and thus capably of functioning in the fatty microenvironments of blood lipids. What’s more, it is more focused against the free radicals of greatest significance (SORAC and HORAC activity). Analysis by Brunswick Labs reveals that hydroxytyrosol has a Total ORAC activity value of over 68,500 µmole TE/g with more than 37 percent as SORAC and 35 percent as HORAC.<br /> <br /> This theory is now scientifically proven, as described in a 2011 European Food Safety Authority Opinion Paper. The opinion paper validates the theory that 5 mg of hydroxytyrosol per day offers protection of blood LDL lipids from oxidative damage. Compared to the 250 mg of vitamin C, purported to act similarly, hydroxytyrosol is clearly more effective.<br /> <br /> The example of olive hydroxytyrosol demonstrates that specialized combinations of antioxidant activities perform better than nutrients with random activities. It shows that we now have the ability to combat the health robbing effects of these rogue molecules far more effectively than ever before. Nature’s Plus’ new Ageloss products employ this knowledge to customize antioxidant activity and address structure and function-specific free radicals more effectively than ever before, and represent the future of antioxidant and anti-aging nutrition.<br /> <br /> Saline Offers a Safe & Effective Approach for Sinusitis Sufferers<br /> <br /> The majority of Americans will suffer from some type of nasal issue at some point in their lives. Whether it is a deviated septum, acute or chronic sinusitis, inflammation or even just a runny nose, people need relief. These conditions are uncomfortable at best and can be debilitating in their most severe forms. According to the Center of Health Statistics, more than 32 million adults are affected by chronic sinusitis, making it one of the most common chronic diseases in the United States. Sinusitis is the inflammation of the nasal sinuses; the frequency and duration of the symptoms determine if it is acute or chronic.<br /> <br /> According to a Mayo Clinic study, fungus is the main cause of sinusitis. In that same study, the Mayo Clinic stated that “antibiotics don’t help chronic sinusitis in the long run because they target bacteria, which are not usually the cause of chronic sinusitis.” Sinus infections can be caused by bacteria or fungi, and a recent Mayo Clinic study suggests that sinusitis can be caused by mold. By using a saline-based nasal spray or solution to rinse the nasal passages, Dr. Pallanch of the Mayo Clinic believes “this can decrease the presence of triggers,” thus minimizing sinusitis symptoms.<br /> <br /> Saline (also known as saline solution) refers to a mixture of water and sodium chloride (NaCl, more commonly known as salt). This solution can only be called sterile when delivered parenterally (via a route other than the mouth), for example, intravenously or directly into the nasal passage. This distinction is important because if not taken this way, it is simply salt water, not saline, North American Herb & Spice’s sea salt solution is the perfect combination of salt and filtered spring water to maximize the sodium chloride in the solution. SinuOrega is a natural nasal wash that combines this saline base with the essential oils of oregano, bay leaf, sage and clove. This is the ideal blend of essential oils and sea salt to help thoroughly rinse the nasal passage. <br /> <br /> Saline nasal irrigation has its roots in homeopathic medicine and for years has been used in the treatment of nasal and sinus disorders. For many years saline nasal irrigation has been a recommended option in chronic sinusitis treatment. Doctors agree that rinsing the nasal passages with a saline nasal spray can help relieve sinusitis symptoms such as inflammation and pressure. Even those who have a deviated septum may be given a saline irrigation for their treatment to help reduce those symptoms.<br /> <br /> More doctors are researching the efficacy of nasal saline irrigation. With bacteria becoming more and more resistant to antibiotics, doctors are looking for more natural remedies for sinus infections. Many doctors believe that, for maintenance therapy, clinicians should use nasal saline irrigation. SinuOrega is right in line with this recommendation. Research done by the Department of Family Medicine at the University of Wisconsin states that using a daily “saline nasal irrigation improves sinus-related quality of life, decreases symptoms, and decreases medication use in patients with frequent sinusitis.” For those who undergo surgery for sinusitis, doctors often recommend using a saline nasal irrigation post-operation to ensure the nasal passage stays moist and clear.<br /> <br /> Research shows fungus and mold spores flourish in the air we breathe. They enter our bodies while we breathe and then thrive upon the sugar in our diet. So it is very important to not only keep our environment clean, but to keep our bodies free of the things that allow mold and fungus to flourish. The choice is clear that a high quality saline solution is effective for sinus cleansing, and SinuOrega is the superior choice to aid in the cleansing process. The powerful combination of wild-crafted essential oils exhibits a preservative effect, keeping the solution sterile. SinuOrega therefore not only cleanses, but maintains a sterile environment, allowing for multiple uses without worry. It does all of this without the use of any synthetic chemicals, pharmaceuticals or additives.<br /> <br /> SinuOrega is available in single units as well as in a 12 unit display pack with special pricing.<br /> <br /> Clinical Evidence for Specific Probiotics Supporting Healthy<br /> Immune Systems<br /> <br /> The intestinal epithelium is a continuous physical-functional barrier protecting our internal environment against undesirable external influences. Surface disruptions cause the loss of epithelial cells, degrading our immune barriers. Disruptive factors include reactions to dietary components, gastrointestinal secretory substances and microbes (xenobiotics).1 <br /> <br /> Probiotics are defined as products which contain viable non-pathogenic microorganisms able to confer health benefits to the host.2 In a healthy adult, cells of microorganisms are estimated to outnumber human cells by a factor of 10:1.3 Aging changes our gut microbiota (microbial community) composition and alters immune system function. There are many studies of adults linking altered gut microbiota with health problems such as irritable bowel syndrome and inflammatory bowel issues. Probiotics, prebiotics and related factors may improve the health status of seniors by modifying their gastrointestinal (GI) environment and improving the composition of the microbial community, which modulate the immune system.4 <br /> <br /> Bacteria form colonies and communicate both among themselves and with intestinal cells. Communication between natural killer and dendritic cells is expedited via immunomodulation by certain bacterial probiotics such as Lactobacillus acidophilus.5 Immune problems may be caused by miscommunication between bacteria and our cells, especially certain autoimmune reactions.6 <br /> <br /> Each probiotic strain has specific health benefits, but not every health benefit associated with probiotic use. A probiotic’s origin (soil, food, human feces) doesn’t guarantee benefits, either; a strain must be:<br /> <br /> • An identifiable safe species<br /> <br /> • Proven to have human health benefits<br /> <br /> • Bile- and acid-resistant<br /> <br /> • Viable in retail packaging Research indicates that some probiotic strains promote health-related functions, including host resistance to infectious microbes.7 Immune competency requires a balanced interaction of microflora, gut epithelium and host immune cells. Disruption of these structural interactions contributes to immune dysfunction and inflammation typical of inflammatory bowel issues. Lactobacillus bacteria have been successful in helping address these issues.8 <br /> <br /> Here are two examples of the clinical science supporting strain-specific probiotic bacteria use:<br /> <br /> Lactobacillus acidophilus NCFM: <br /> <br /> In a study of healthy children 3-5 years old without known pre-existing diseases, probiotic supplementation with L. acidophilus NCFM (10 billion CFU/day) reduced the incidence and duration of fever, rhinorrhea and cough, and the incidence of antibiotic prescriptions, compared with the placebo group. Daily supplementation of L. acidophilus NCFM for six months was a safe, effective way to reduce fever, rhinorrhea and cough incidence and duration, and prescription incidence, as well as the number of missed school days attributable to illness.2 <br /> <br /> In mouse studies, oral administration of L. acidophilus NCFM effectively reduced colon tumor growth and the extent of affected tissues versus controls. 9<br /> <br /> L. acidophilus NCFM has several positive characteristics. It survives passage through the GI tract and positively influences the gut microflora. In healthy adults, consumption increases the number of lactobacilli in the feces but with no effect on levels of bifidobacteria or sulfide-producing bacteria.10 <br /> <br /> Bifidobacterium lactis Bl-04: <br /> <br /> In a pilot study of healthy adults, B. lactis Bl-04 (20 billion CFU/day) modulated immune responses and induced a faster increase in serum IgG concentrations than several other probiotic strains or a placebo.11 <br /> <br /> Lactobacillus acidophilus NCFM with Bifidobacterium lactis Bl-04: <br /> <br /> In a four-month, double-blind, randomized study, 47 children with birch pollen allergy received this probiotic combination (5 billion CFU/day) or placebo. The allergy changed fecal microbiota composition. Symptoms were recorded in a diary. The strains were selected based on their anti-inflammatory properties and immune effects. Blood samples were taken for analysis of cytokines and eosinophils, and nasal swabs for eosinophils. Fecal samples were analyzed for microbiota components, calprotectin, and IgA. This specific combination of probiotics prevented pollen-induced infiltration of eosinophils into nasal mucosa, with a trend for reduced nasal symptoms.12 <br /> <br /> These examples show the power of specific strains of probiotic bacteria to support healthy immunity in the human body. These strains can be found in NOW Foods’ Clinical Probiotic Immune.<br /> <br /> For a full list of references, visit www.vitaminretailer.com<br /> <br /> Without Magnesium, Vitamin D & Calcium Alone Will Not Prevent Bone Fractures<br /> <br /> The U.S. Preventive Services Task Force, a government-appointed panel of experts, recently issued a report stating that taking vitamin D and calcium supplements may not help prevent bone fractures in postmenopausal women, while also increasing the risk of kidney stones.1 <br /> <br /> This is not surprising because adequate levels of magnesium in the body are essential for the absorption and metabolism of vitamin D and calcium.<br /> <br /> Magnesium converts vitamin D into its active form so that it can help calcium absorption and help prevent clogged arteries by drawing calcium out of the blood and soft tissues back into the bones where it is needed to build healthy bone structure.<br /> <br /> Nutrients act in a synergetic way in the body. Absorption and metabolism of a particular nutrient will be affected, to a greater or lesser degree, by the other nutrients available to the body. This is also true with vitamin D. <br /> <br /> According to the nonprofit Vitamin D Council, “In order to receive the most health benefit from increased levels of vitamin D, the proper cofactors must be present in the body. Vitamin D has many cofactors, but the ones listed here are the most important, with magnesium topping the list: magnesium, vitamin K, vitamin A, zinc and boron.” <br /> <br /> According to research studies, magnesium has been found to influence the body’s utilization of vitamin D in the following ways: Magnesium activates cellular enzymatic activity. In fact, all the enzymes that metabolize vitamin D require it.2,3 Low magnesium has been shown to alter, by way of decreasing, production of vitamin D’s active form, 1,25(OH)2D (calcitriol).4 <br /> <br /> Magnesium is needed to exert positive influence over the human genome and may be involved in the genetic actions of vitamin D. Magnesium possibly has a role in vitamin D’s effect on the immune system.5 <br /> <br /> Animal studies have shown magnesium is also necessary for vitamin D’s beneficial actions on bone.6,7 <br /> <br /> It is vitally important that studies on the efficacy of vitamin D and calcium in relation to bone health are not done in isolation in the absence of magnesium. The fact that magnesium works synergistically with vitamin D and calcium by stimulating the specific hormone calcitonin—which helps to preserve bone structure and draws calcium out of the blood and soft tissues back into the bones, preventing osteoporosis, some forms of arthritis and kidney stones—cannot be overlooked.<br /> <br /> The many studies pointing to the importance of these two nutrients to the prevention of both heart disease and osteoporosis, and the fact that magnesium can be found to increase the effectiveness of vitamin D and calcium, make finding out about this vital mineral that much more important.<br /> <br /> Apoaequorin Provides Memory Benefits for Boomer & Senior Market<br /> <br /> When Baby Boomers and Seniors were asked their biggest concern about aging, the No. 1 answer was maintaining mental capacity.1 According to the Natural Marketing Institute’s “Healthy Aging Survey,” the ability to remember was even more important than other challenges common in aging.<br /> <br /> Supporting healthy brain function is a crucial need now more than ever due to the sheer size of this age cohort. Beginning back in January 2011, the oldest members of the 78 million Baby Boomers turned 65. Every day for the next 19 years, 10,000 more will reach 65 years of age.2 <br /> <br /> In normal aging, mild memory problems can occur as a result of excessive intracellular calcium caused by poorly supported calcium-binding proteins. These proteins help to support brain function. Supplementing these proteins, which can be negatively affected by aging, has shown to support brain cell function in pre-clinical studies and to improve memory in humans.<br /> <br /> Apoaequorin is a calcium-binding protein originally discovered in jellyfish and is the main ingredient in the memory supplement Prevagen.* <br /> <br /> Safety of Apoaequorin <br /> <br /> Apoaequorin was originally obtained from the luminescent jellyfish species Aequorea victoria, and is now produced in a recombinant fermentation process. The safety of apoaequorin is well-established based on the results of both acute and sub-chronic toxicology investigations. The sub-chronic toxicity study in rats recently published found that at 2,000 times equivalent human dosing, there were no clinical or ophthalmological signs, body weight, body weight gain, food consumption, food efficiency, clinical pathology or histopathological changes attributable to administration of apoaequorin.<br /> <br /> Based on critical evaluations and the acceptance of a qualified, independent scientific panel, apoaequorin is now self-affirmed GRAS (generally recognized as safe) and can be utilized as a food ingredient.<br /> <br /> Effectiveness of Apoaequorin <br /> <br /> The effect of apoaequorin on cognition was measured in a large double-blind, placebo-controlled trial. Two hundred and eighteen adult participants over the age of 40 with mild memory concerns were assessed five times over a 90-day period using a widely accepted computer- based cognitive testing protocol developed by Cogstate, Ltd.4 <br /> <br /> Overall, participants in the Prevagen arm saw a significant positive change over the three-month study period in the following areas:<br /> <br /> • Verbal learning*<br /> <br /> • Memory*<br /> <br /> • Delayed recall*<br /> <br /> • Executive function* <br /> <br /> Additionally, the participants scoring 0-1 on the AD8 screening test experienced a robust reduction in total errors of 29 percent compared to baseline.<br /> <br /> Presently, Prevagen is the only dietary supplement to contain apoaequorin. Prevagen Extra Strength contains 20 mg of apoaequorin, which is twice the level of Prevagen, and Prevagen Professional has 40 mg of apoaequorin per capsule— four times consumer strength Prevagen. Prevagen Professional is exclusive to the health care practitioner channel.<br /> <br /> The data suggests Prevagen is a safe and potentially effective approach to help those beginning to experience mild memory problems in aging such as forgetting why someone walked from one room to the next or having difficulty finding words in a conversation.*<br /> <br /> Naturally Derived Fiber in Calorease Binds Fat in Foods, Reduces Daily Calories<br /> <br /> New Calorease weight management tablets take advantage of a breakthrough in the science of dietary fibers. The primary challenge with weight management is to reduce daily calories to ensure a calorific deficit; that is, more calories out than in. However, methods that rely upon making dramatic changes to dietary habits have a high failure rate, as they are difficult to sustain. By binding to the fat in foods to reduce up to 500 calories a day, Calorease offers a weight management aid without the restrictions of a low fat diet.<br /> <br /> Typically, dietary fibers bind fat in a 1:1 ratio, meaning that one must consume unmanageable quantities for effective weight management. But the fiber in Calorease, called FBCx, stands out for its weight management capacity. It is patented for its impressive ability to bind and eliminate up to nine times its weight in dietary fat.<br /> <br /> The purity and unique structure of the fiber in Calorease allows it to form a stable, non-digestible complex with dietary fat. Furthermore, it has a high affinity with saturated fats, preferentially binding to and removing these undesirable fats.<br /> <br /> Naturally sourced from grain, the fiber in Calorease, FBCx (alpha-cyclodextrin), is generally recognized as safe (GRAS) by the FDA. It’s also reassuring to know that while the Calorease fiber-fat complex is non-digestible, it is also non-fermentable, eliminating messy side effects often associated with pharmaceutical products, that inhibit fat absorption. When taken as directed—two tablets with meals or snacks containing fat—no negative reactions are reported.<br /> <br /> Calorease is also vegan and contains no gluten, lactose, yeast, wheat, sugar, salt, egg, soy, dairy, artificial colors, sweeteners or preservatives.<br /> <br /> Clinical Studies Support Calorease <br /> <br /> Two professors at Wayne State University in Detroit, MI first recognized the significant potential of FBCx. They initiated studies to demonstrate its role in aiding weight management and in helping to maintain healthy blood cholesterol levels. The fat-binding properties of FBCx, the active ingredient in Calorease, have now been well researched and documented. Multiple studies, including a clinical trial currently underway at the National Institutes of Health (NIH, Bethesda, MD), add to increasing evidence that Calorease with FBCx can effectively aid weight control and healthy cholesterol management.<br /> <br /> • Comerford KB et al. Study on Overweight Individuals This encompassed a double-blind, placebo-controlled, two-month crossover study in healthy overweight, non-obese individuals where participants were instructed not to change eating or activity programs.<br /> <br /> Results: Statistically significant reduction of weight, total cholesterol, and LDL-cholesterol (bad cholesterol).<br /> <br /> Calorease Conveniently Packages <br /> <br /> FBCx Benefits As a weight management tool, Calorease tablets are easy to understand, sell and use. Tablets are packaged in 90- or 180-ct. Blister packs, lasting 15+ to 30+ days, with convenient go-anywhere serving pouches.<br /> <br /> With Calorease, there is no special program or diet necessary, although a reduced calorie diet and exercise plan is recommended to achieve maximum benefits. Most of us consume about 100 grams of fat a day, and taking two Calorease tablets with fat-containing meals or snacks, three times a day, will bind up to half of that fat and its associated calories. That is, at the recommended six tablets per day, up to 54 grams of fat will be bound and reduced daily—that’s up to 500 fewer calories absorbed. It quickly adds up to as much as 15,000 calories reduced every month! This calorie reduction is without the usual restrictions of a low fat diet, which makes Calorease an effective tool that delivers the edge to weight management efforts.<br /> <br /> Calorease tablets are manufactured in the U.S., with fiber derived from natural, domestically grown grain. The breakthrough fiber ingredient, FBCx, is patented in more than 30 countries. Ongoing clinical trials in the U.S., Australia and Europe, and research will further verify the efficacy and value of FBCx and Calorease.<br /> <br /> Find more information about Calorease and its fat-binding benefits at www.calorease.com<br /> <br /> BluCetin: A Natural Hangover Protection Supplement<br /> <br /> As early as the year 659, Chinese herbalists have been credited with using extracts of the Hovenia dulcis, commonly known in the U.S. as oriental or Japanese raisin tree, fruit to treat alcohol-induced liver damage and prevent hangovers. In January 2012, a groundbreaking study1 evaluating the use of the extract in the reduction of alcohol-induced intoxication and curbing alcohol craving was released. The results were astounding and researchers had identified and isolated the active component of the tree, dihydromyricetin (DHM), the main ingredient in BluCetin™.<br /> <br /> The lead investigators, Drs. Liang and Olsen, discovered that DHM blocked alcohol at the GABA-receptor sites, reducing unwanted alcohol effects such as motor impairment, alcohol withdrawal symptoms and craving for alcohol consumption. In the study, motor impairment was measured by loss of righting reflex (LORR). When animal models took DHM 30 minutes prior to alcohol consumption, subjects had an 80 percent reduction in motor impairment compared to placebo (LORR 8.2 + 4. 2 min compared to LORR 42 + 9.1 min). Even subjects taking DHM 30 minutes after alcohol consumption still noted a 55 percent reduction in motor impairment (LORR 19 + 1.0 min). Anxiety, a symptom of alcohol withdrawal, was reduced in animal subjects with DHM. Cravings for alcohol consumption were measured over four weeks. By the end of the second week, animal subjects with only alcohol had increased their alcohol consumption to 3. 9 + 1.4 g/kg/day. By the start of the fourth week, consumption had doubled to 7.4 + 0.6 g/kg/day. In subjects with DHM and alcohol, alcohol consumption remained statistically significantly lower compared to subjects with only alcohol. By the start of the fourth week, alcohol consumption had only increased to 2.5 + 0.5 g/kg/day.<br /> <br /> It was well known that DHM’s antiinflammatory and antioxidant properties protected and allowed the liver to recover from alcohol damage. This study clearly proved that DHM also possessed central and systemic mechanisms of action against alcohol. nIn the study, investigators determined that similar to alcohol, DHM binds to the GABA-receptor sites in the brain. By blocking alcohol from the receptor sites, DHM effectively reduced motor impairment during alcohol consumption, craving for alcohol and related withdrawals symptoms.<br /> <br /> The momentum of the study did not stop there. In January 2013, a crossover study2 with 12 adult volunteers was conducted by the manufacturer called “Effects of BluCetin on the Impact of Alcohol in Humans: A Pilot Study.” The objective was to discover the acute effects of BluCetin in adults during alcohol consumption. Primary outcomes of blood alcohol concentrations, motor reflexes and hangover symptoms were used to measure the effectiveness.<br /> <br /> Motor reflexes were tested using the standard stop light reaction test and the straight-line walk. The blood alcohol concentration study was based on a single drink (8.5-oz) of whiskey 30 minutes after taking BluCetin or placebo (Figure 1) . Under BluCetin the blood alcohol concentrations of all participants were lower than placebo at every measurement (Figure 5) . At the same time participants had a faster reaction time in the standard stop light reaction test, scored higher on the straight-line walk and scored better in the hangover evaluation than placebo.<br /> <br /> BluCetin is a high quality natural supplement used to reduce hangovers associated with social drinking. Social drinking is defined as consuming a daily average of two alcoholic servings for males and one serving for females. If drinking is rare, such as once a month, social drinking can include up to three servings for males per day and two servings for females. To maximize the benefit of BluCetin, the first tablet should be taken 30 minutes before the first drink. Additional tablets can be taken while drinking to regain some control or prevent further intoxication. To ensure rapid elimination of alcohol and avoid hangovers, it is recommended to take another tablet after drinking before going to bed. The maximum number of tablets per occasion is four.<br /> <br /> When taken appropriately, BluCetin can be beneficial for those who want to enjoy occasions where moderate alcohol consumption is expected. From birthday dinners to weddings, BluCetin puts the social drinker more in control while protecting the liver and brain from the unpleasant effects of alcohol intoxication.<br /> <br /> Silent Killer, Simple Solution<br /> <br /> Ask the average woman to name the most serious health threat to women and she will probably say “breast cancer.” Guys usually think that theirs is “heart attacks caused by high cholesterol.” But both are wrong.<br /> <br /> Breast cancer may be top of mind, but heart disease claims more women than the next seven causes combined. Likewise, the billions spent advertising cholesterol-lowering drugs blur the fact that cholesterol numbers are just one controversial aspect of heart health. In fact, half of those who die from heart attacks had normal cholesterol! High cholesterol is “associated” with increased incidence of heart attacks. However, “associated with” is not a causal relationship. It only means that the two factors often appear together— like fire trucks and house fires. The real question is “why does cholesterol go up?” <br /> <br /> The body uses cholesterol to make hormones and vitamin D. It is also a repair molecule and many experts believe that cholesterol is the “fire truck” at the scene of the blaze (damage to arteries). Smoking, heavy metals, environmental chemicals and toxins released by bacteria in our gums are a few suspected causes of the damage. Cholesterol itself can become an irritant if oxidized and not restored by antioxidants like vitamin E. A big, under-recognized cause of inflammation damage to the blood vessels is homocysteine.1 Homocysteine is a naturally occurring amino acid that is a breakdown product of the essential amino acid, methionine.<br /> <br /> Homocysteine elevation is linked to cancer and is a cause of deep vein thrombosis, stroke (even in young women) as well as reduced physical performance in older women. The concept of homocysteine as a “cardio bad guy” has been investigated since at least 1969, with Harvard researcher Dr. Kilmer McCully pioneering the field. We know that, as blood levels of homocysteine rise, the risk of developing severe coronary heart disease rises proportionately. In one study, women with the highest homocysteine measurements (the top 10 percent) had 2.3 times the heart attack risk of women in the lower half of the scale. (The women with high homocysteine levels also tended to have low folic acid levels.)<br /> <br /> Normally, homocysteine is converted into a harmless amino, cysteine, or back into methionine. Gluten sensitivity may increase homocysteine buildup but the usual problem is low B vitamins. Most nutrition-savvy doctors recommend supplementing with folic acid to help homocysteine normalize as well as B6 and B12 for their well-documented fringe benefits. Folic acid is crucial for proper cell division and so helps prevent cancer and neural tube birth defects. Low folic acid may account for 40 percent of cases of autism.2 <br /> <br /> Supplementing B12 with folic is important in part because high blood levels of folic acid can make it harder to detect a vitamin B12 deficiency in routine blood tests. Also, in her book Could It Be B12?: An Epidemic of Misdiagnoses, Sally M. Pacholok, RN said B12 deficiency “afflicts one person with tremors, makes another depressed or psychotic, and causes agonizing leg and arm pains or paralysis … can mimic Alzheimer’s disease, multiple sclerosis, early Parkinson’s disease, diabetic neuropathy or chronic fatigue syndrome. It can make men or women infertile or cause developmental disabilities in their children … it lurks silently, stealthily increasing its victim's risk of deadly diseases ranging from stroke and heart attacks to cancer.” <br /> <br /> Vitamin B6 has dozens of textbook roles including helping nerve function, forming red blood cells and utilizing amino acids. It is often employed to reduce PMS symptoms.<br /> <br /> Stumbling blocks to achieving B vitamin sufficiency include:<br /> <br /> 1. Lack of awareness of the importance.<br /> <br /> 2. Poor diet.<br /> <br /> 3. Supplement absorption—especially with the elderly. Stomach acid is required to produce vitamin B12 and seems needed for adequate folic acid absorption, too. Those past middle age may already have reduced stomach acid and acid-blocking heartburn drugs make matters worse.<br /> <br /> 4. Compliance—people do not like to swallow pills.<br /> <br /> Hopefully, retailers can help with Nos. 1 and 2. I solve Nos. 3 and 4 with my clients by recommending Superior Source’s No-Shot Advanced MicroLingual B12/B6/Folic Acid. The tiny pellets dissolve almost instantly and allow the nutrients to go right into circulation under the tongue. Furthermore, B12 is in a meaningful dose, 2,000 mcg and in its preferred active forms, methylcobalamin and adenosylcobalamin (dibencozide). Likewise, B6 is pyridoxal 5'-phosphate. No bulky pills to swallow and the tabs taste great.

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